NCT04485143

Brief Summary

Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) are the golden treatments for stable coronary artery disease (CAD) combined with heart failure (HF). The goal of treating HF patients is to prevent repeated hospitalizations and improve peri-operative survival; clinically, although routines including beta-receptor inhibitors, angiotensin-converting enzyme (ACE) inhibitors, and mineralocorticoids have been shown beneficial for the prognosis, for patients with severely low left ventricular ejection rate, hypotension, and pulmonary disease, the introduction of these drugs in the early postoperative period should still be cautious and may need to be adjusted with related cardiovascular function parameters. Patients with low cardiac output syndrome, ventricular arrhythmia, or hemodynamic instability should be suspected of the failure of bypass grafts if accompanied by changes in the electrocardiogram (EKG) and an increase in myocardial enzymes. Intervention should be carried out as soon as possible after angiography detects graft failure to limit the occurrence of large-scale myocardial injury and prevent the development of severe myocardial failure. This study is start on June 1 2020. And will include 400 patients who have just undergone PCI and 300 CABG patients who diagnosis of stable coronary artery disease. We will register their medical history, medications, and routine medical examinations within one year, and perform tests such as phonocardiography (Audiocor). They will be worn and measured daily at home after discharge. The data of the electrocardiogram and the PPG bracelet will be registered with their continuous daily values. All subjects tracked the occurrence of adverse medical events within one year after discharge from the hospital. Based on the home-based remote personal care model for patients with CABG, a risk prediction model for heart failure and vascular restenosis was established to effectively reduce medical treatment, adverse events, and medical expenditure.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
700

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2020

Longer than P75 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 29, 2020

Completed
21 days until next milestone

Study Start

First participant enrolled

July 20, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 24, 2020

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 20, 2022

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 20, 2024

Completed
Last Updated

July 24, 2020

Status Verified

June 1, 2020

Enrollment Period

2 years

First QC Date

June 29, 2020

Last Update Submit

July 21, 2020

Conditions

Keywords

Percutaneous Coronary InterventionCoronary Artery BypassPhonocardiography, PPGBraceletVascular RestenosisArtificial intelligence

Outcome Measures

Primary Outcomes (3)

  • death

    death, divided into yes or no

    Within a year

  • Restenosis

    Come back to the hospital for PCI or CABG or MI (Judged by the physician) after discharge, divided into yes or no

    Within a year

  • heart failure

    Come back to the hospital for heart failure (Judged by the physician) after discharge, divided into yes or no

    Within a year

Secondary Outcomes (7)

  • heart disease re-hospitalization

    Within a year

  • Stroke re-hospitalization

    Within a year

  • Arrhythmia re-hospitalization

    Within a year

  • Physician adjusts medicine

    Within a year

  • Physician arranges examination early

    Within a year

  • +2 more secondary outcomes

Study Arms (1)

experimental group

Non-invasive Wearable Device

Device: Wisdom bracelet

Interventions

routine medical

Also known as: control group (routine medical)
experimental group

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Age\>=20,Physician diagnosed with stable coronary artery disease (CAD), accepting PCI patients with stents or CABG, and willing to sign the subject consent and cooperate with return. And random allocation 350 experimental group (Non-invasive Wearable Device) and 350 control group (routine medical).

You may qualify if:

  • Age\>=20,Physician diagnosed with stable coronary artery disease (CAD), accepting PCI patients with stents or CABG, and willing to sign the subject consent and cooperate with return.

You may not qualify if:

  • Not eligible
  • Patients judged to be STEMI or NSTEMI by the physician
  • PCI bracket
  • Patients with severe skin damage near the electrode or sensor device.
  • Failure to cooperate in signing consent
  • Those who cannot be admitted to the hospital after the onset and have their first examination before the operation
  • Unable to measure the ECG heart sounds. For example, if you use a heart rate regulator, the ECG will show ventricular tachycardia (VT) and Dextrocardia on admission.
  • Patients who are bedridden and have difficulty in cooperating with return visits
  • Direct participants in this plan

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research DesignEpidemiologic MethodsInvestigative TechniquesResearch DesignMethods

Study Officials

  • Ju-Chi Liu, MD

    Chief, Internal of Medicine

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Year
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 29, 2020

First Posted

July 24, 2020

Study Start

July 20, 2020

Primary Completion

July 20, 2022

Study Completion

July 20, 2024

Last Updated

July 24, 2020

Record last verified: 2020-06