Brief Summary

The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

Trial Health

At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date

Enrollment

2,000

participants targeted

Target at P75+ for all trials

Timeline

Completed

Started May 2017

Longer than P75 for all trials

Geographic Reach

1 country

38 active sites

Status

unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

5 years study duration

First Submitted

Initial submission to the registry

July 7, 2015

Completed

7 days until next milestone

First Posted

Study publicly available on registry

July 14, 2015

Completed

1.8 years until next milestone

Study Start

First participant enrolled

May 12, 2017

Completed

2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2019

Completed

3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2022

Completed

Last Updated

February 21, 2019

Status Verified

February 1, 2019

Enrollment Period

2 years

First QC Date

July 7, 2015

Last Update Submit

February 20, 2019

Conditions

Coronary Artery Disease Percutaneous Coronary Intervention

Keywords

Young PatientGenetic Characteristics

Outcome Measures

Primary Outcomes (4)

Number of cardiac death
Any death from cardiac conditions
36 months
Number of patients developing myocardial infarction
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
36 months
Number of patients developing stroke
Any events of ishcemic stroke, TIA or hemorrhagic stroke
36 months
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
36 months

Secondary Outcomes (1)

Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.
36 months

Study Arms (3)

Early-onset CAD

The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

Late-onset CAD

The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

Age-matched controls

The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

Eligibility Criteria

Age18 Years - 45 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodProbability Sample

Study Population

Patients aged ≤45 years diagnosed with CAD by coronary angiography will be collected from multiple institutions.

You may qualify if:

premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
age matched individuals who had coronary arteries without obvious stenosis.

You may not qualify if:

severely sick with limited life-expectancy \< 1 year;
patients with malignancies;
pregnant or planning for pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Shanghai Zhongshan Hospitallead

Study Sites (38)

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

RECRUITING

Xiamen Cardiovascular Hospital

Xiamen, Fujian, China

RECRUITING

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

RECRUITING

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

RECRUITING

Sun yat-sen Memorial Hospital

Guangzhou, Guangdong, China

RECRUITING

Zhuhai Hospital of Guangdong Provincial People's Hospital

Zhuhai, Guangdong, China

RECRUITING

The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine

Nanning, Guangxi, China

RECRUITING

Affiliated Hospital of Zunyi Medical College

Zunyi, Guizhou, China

RECRUITING

The second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

RECRUITING

Wuhan Asia Heart Hospital

Wuhan, Hubei, China

RECRUITING

Wuxi Third People's Hospital

Wuxi, Jiangsu, China

RECRUITING

Xuzhou Fourth People's Hospital

Xuzhou, Jiangsu, China

RECRUITING

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

RECRUITING

The second Hospital of Jilin University

Changchun, Jilin, China

RECRUITING

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

RECRUITING

The First Affiliated Hospital of Xi 'an Jiaotong University

Xi'an, Shaanxi, China

RECRUITING

Shanghai Zhongshan Hospital

Shanghai, Shanghai Municipality, 200032, China

RECRUITING

Central Hospital of Jiading District