Frequency of Perforated Appendicitis in Times of COVID-19

NCT04472052 | Completed

• 1 other identifier: AZ: 324/2020BO2
• Study Type: observational
• Target: 143
• Locations: 1 country
• Sites: 1

Brief Summary

Appendicitis is one of the most common clinical conditions in general surgery. The diagnosis is usually made from clinical examination, imaging (sonography or CT) and laboratory parameters. The laparoscopic appendectomy without drainage has established as the gold standard. Patients usually leave the hospital two days after surgery. In times of corona crisis, patients are unsure to visit the hospital because of fear of infection with SARS-CoV-2. A higher incidence of perforated appendicitis could be an indicator for fear-related delay of going to the hospital. Methods: Investigators performed a retrospective analysis on the incidence of perforated appendicitis in a 10-week interval (mid-March to end of May) of the years 2018, 2019 and 2020 to evaluate possible changes in times of corona crisis. Intraoperative findings, procedures, complications and the length of hospital stay were considered.

Conditions

Perforated Appendicitis; Covid19

Keywords

acute appendicitis, COVID-19

Outcome Measures

Primary Outcomes (1)

• rate of perforated appendicitis

  10 weeks from 16th of March to 31th of May

Study Arms (1)

Appendectomy

Patients who required appendectomy for suspected acute appendicitis

Other: appendectomy

Interventions

appendectomy OTHER

Surgical standard treatment for acute appendicitis All patients receive preoperative single-shot antibiosis, usually 2000 mg cefotaxime combined 500 mg metronidazole. Appendectomy is performed usually within 24 h of admission in patients with acute appendicitis. The laparoscopic appendectomy using the 3-trocar technique represents the surgical standard. In uncomplicated or non-perforated appendicitis, drainage is generally not required. Wounds are closed intra-cutaneous with absorbable sutures. Patients without postoperative complications are discharged home two days after surgery.

Appendectomy

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with acute appendicitis

You may qualify if:

• patients with acute appendicitis older than 16 years
• appendectomy in time frame 16th of march to 30th of May in the Years 2018, 2019 and 2020

You may not qualify if:

• patients with acute appendicitis younger than 16 years
• appendectomy not in the named time frames

Sponsors & Collaborators

• University Hospital Tuebingen: lead

Study Sites (1)

University Hospital of Tuebingen

Tübingen, 72076, Germany

Location

MeSH Terms

Conditions

Appendicitis; COVID-19

Interventions

Appendectomy

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Digestive System Surgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 10, 2020
• First Posted: July 15, 2020
• Study Start: March 16, 2020
• Primary Completion: May 31, 2020
• Study Completion: May 31, 2020
• Last Updated: July 15, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)