Presentation and Outcomes of Acute Appendicitis During COVID Pandemic
AA
1 other identifier
interventional
1,945
1 country
1
Brief Summary
Acute appendicitis (AA) is a frequent cause of acute abdominal pain in emergency rooms around the world \[1\]. The lifetime risk of developing AA is estimated to be about 8% \[1-3\]. The severe acute respiratory syndrome SARS-CoV-2 Coronavirus (COVID-19) pandemic has raised difficult situations for healthcare systems and organizations around the world, with direct and indirect implications for patient care delivery. COVID-19 causes a wide range of clinical symptoms, including fever, dry cough, myalgia, and exhaustion, with pulmonary involvement in many cases. According to the World Health Organization (WHO), The effect of the COVID-19 pandemic on acute appendicitis and surgical care is unknown due to a lack of evidence. To see how appendicitis care has changed as a result of the COVID-19 pandemic, this study compares clinical presentation, investigative modalities, treatment procedures, and outcomes before and after the pandemic.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2019
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 31, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2021
CompletedFirst Submitted
Initial submission to the registry
October 31, 2021
CompletedFirst Posted
Study publicly available on registry
November 3, 2021
CompletedNovember 8, 2021
November 1, 2021
2 years
October 31, 2021
November 1, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
the management strategy used
the management strategy used, which included conservative or surgical management (open or laparoscopic).
one month
Secondary Outcomes (3)
clinical presentation
one month
postoperative complications
one month
the negative appendicectomy rate.
one month
Study Arms (2)
Patients in group I (G1) had AA prior to the era of COVID
PLACEBO COMPARATORPatients in group I (G1) had AA prior to the era of COVID
patients in group II (G2) had AA during COVID
ACTIVE COMPARATORpatients in group II (G2) had AA during COVID
Interventions
open or laparoscopic appendectomy
Eligibility Criteria
You may qualify if:
- patients with acute appendicitis
You may not qualify if:
- patients with acute appendicitis less than 12 years
- malignant appendix
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ayman El Nakeeb
Al Mansurah, 335111, Egypt
Related Publications (6)
Kim CW, Lee SH. Impact of COVID-19 on the care of acute appendicitis: a single-center experience in Korea. Ann Surg Treat Res. 2021 Oct;101(4):240-246. doi: 10.4174/astr.2021.101.4.240. Epub 2021 Oct 1.
PMID: 34692596RESULTKohler F, Muller S, Hendricks A, Kastner C, Reese L, Boerner K, Flemming S, Lock JF, Germer CT, Wiegering A. Changes in appendicitis treatment during the COVID-19 pandemic - A systematic review and meta-analysis. Int J Surg. 2021 Nov;95:106148. doi: 10.1016/j.ijsu.2021.106148. Epub 2021 Oct 23.
PMID: 34700020RESULTZheng Z, Bi JT, Liu YQ, Cai X. The impact of COVID-19 pandemic on the treatment of acute appendicitis in China. Int J Colorectal Dis. 2022 Jan;37(1):215-219. doi: 10.1007/s00384-021-04031-4. Epub 2021 Oct 13.
PMID: 34647160RESULTAl Hashmi FY, Al Zuabi A, Hachim IY, Mannaerts GHH, Bekdache O. Conservative management of acute appendicitis in the era of COVID 19: A multicenter prospective observational study at the United Arab Emirates. Int J Surg Open. 2021 Oct;36:100389. doi: 10.1016/j.ijso.2021.100389. Epub 2021 Aug 25.
PMID: 34568625RESULTFarber ON, Gomez GI, Titan AL, Fisher AT, Puntasecca CJ, Arana VT, Kempinsky A, Wise CE, Bessoff KE, Hawn MT, Korndorffer JR Jr, Forrester JD, Esquivel MM. Impact of COVID-19 on presentation, management, and outcomes of acute care surgery for gallbladder disease and acute appendicitis. World J Gastrointest Surg. 2021 Aug 27;13(8):859-870. doi: 10.4240/wjgs.v13.i8.859.
PMID: 34512909RESULTRudnicki Y, Soback H, Mekiten O, Lifshiz G, Avital S. The impact of COVID-19 pandemic lockdown on the incidence and outcome of complicated appendicitis. Surg Endosc. 2022 May;36(5):3460-3466. doi: 10.1007/s00464-021-08667-9. Epub 2021 Jul 26.
PMID: 34312724RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ayman El E El Nakeeb
Mansoura University, Gastrointestinal Surgery Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Gastroenterology surgical center, mansoura university
Study Record Dates
First Submitted
October 31, 2021
First Posted
November 3, 2021
Study Start
March 31, 2019
Primary Completion
March 31, 2021
Study Completion
October 1, 2021
Last Updated
November 8, 2021
Record last verified: 2021-11
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL
- Time Frame
- available for any researcher at any time
- Access Criteria
- elnakeebayman@yahoo.com
the study protocol will be available for other researcher