NCT04433936|Completed
Corneal Tomographic Parameters in TGD
Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction.
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Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction.
Sponsor study identifier
observational
100
1 country
1
Study Start
February 1, 2018
Actual (reported)Primary Completion
June 1, 2018
Actual (reported)Study Completion
June 1, 2018
Actual (reported)The current study involved analysis of the corneal tomographic parameters of patients with thyroid gland dysfunction (hyperthyroidism or hypothyroidism), including those with an autoimmune etiology, in comparison to healthy controls without TGD, using pentacam, in an attempt to detect possible early corneal changes and to highlight whether early screening of those patients would be necessary for early detection of KC.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 1, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 1, 2018
Actual (reported)June 1, 2018
Actual (reported)June 1, 2018
Actual (reported)June 13, 2020
Actual (reported)June 16, 2020
Actual (reported)corneal tomographic parameter
analysis of pentacam maps
1 day (once at first recruitment)
Patients with a recent diagnosis of TGD (the study group) were recruited from endocrinology outpatient clinic of Specialized Medical Hospital, Mansoura University. Diagnosis of TGD was based on précised history, clinical examination and laboratory investigations. In order to avoid bias, patients with history of intake of any thyroid-related medications (antithyroid medications or thyroxine replacement), radioactive iodine or thyroidectomy were excluded from the study.
fifty age and gender matched healthy subjects without known personal or family history of thyroid disease or any autoimmune diseases were recruited from candidates of refractive surgery referred to the outpatient clinic of Mansoura Ophthalmology Center for pentacam assessment and who were proved to have normal corneal pentacam parameters. They were further examined by the endocrinologist to exclude thyroid dysfunction; this was supported by normal thyroid function profile (serum TSH and free T4) and negative anti-TPO and antithyroglobulin antibodies.
The Pentacam maps were analyzed. The following anterior and posterior corneal surface parameters were evaluated by the Scheimpflug system: Kf, Ks, Kmax. The pachymetric map was analyzed, including CCT at the apex of the geometric center and CTmin. PPIavg, PPI min and PPI max were calculated . The Ambrósio relational thickness (ART) was calculated The posterior corneal elevation maps were evaluated and the posterior corneal elevation values relative to this reference were recorded. The back difference elevation and multimetric D index values were extrapolated from the difference map of the Belin/Ambrósio-enhanced ectasia display of the Pentacam system.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
100 eyes of 50 patients with TGD (hypo-hyperthyroidism) and 100 eyes of 50 age and sex matched healthy controls.
Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt
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Rania Bassiouny, MD
Mansoura University
100 participants (actual enrollment reported by the registry).
First Submitted
June 13, 2020
First Posted
June 16, 2020
Study Start
February 1, 2018
Actual (reported)Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light
Contact the study team to confirm eligibility.
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Primary Completion
June 1, 2018
Actual (reported)Study Completion
June 1, 2018
Actual (reported)Last Updated
June 16, 2020
Record last verified: 2020-06
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