Key Insights

Highlights

Success Rate

85% trial completion

Published Results

14 trials with published results (5%)

Research Maturity

112 completed trials (43% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 52/100

Termination Rate

7.7%

20 terminated out of 259 trials

Success Rate

84.8%

-1.7% vs benchmark

Late-Stage Pipeline

12%

30 trials in Phase 3/4

Results Transparency

13%

14 of 112 completed with results

Key Signals

14 with results85% success20 terminated

Data Visualizations

Phase Distribution

176Total
Not Applicable (104)
Early P 1 (2)
P 1 (12)
P 2 (28)
P 3 (26)
P 4 (4)

Trial Status

Completed112
Unknown67
Recruiting26
Terminated20
Active Not Recruiting13
Not Yet Recruiting10

Trial Success Rate

84.8%

Benchmark: 86.5%

Based on 112 completed trials

Clinical Trials (259)

Showing 20 of 20 trials
NCT07559188Not ApplicableNot Yet RecruitingPrimary

Proof-of-Concept for a Novel Optical Aperture Contact Lens in Presbyopia and Keratoconus

NCT07553832Not Yet RecruitingPrimary

Clinical and Subclinical Keratoconus Cohort Study

NCT03923101RecruitingPrimary

The Homburg Keratoconus Center (HKC)

NCT07474870Phase 4Not Yet RecruitingPrimary

Outcomes of CTAK Surgery

NCT02138669Not ApplicableRecruitingPrimary

Intacs Prescription Inserts for Keratoconus Patients

NCT04584125Not ApplicableNot Yet RecruitingPrimary

A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients

NCT07497815Not Yet Recruiting

Artificial Intelligence-assisted Diagnosis in Ophthalmology

NCT04392349Not ApplicableCompleted

Clinical Study - ES 900 - 2020-2

NCT06235567Phase 1Enrolling By InvitationPrimary

Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking

NCT07468253CompletedPrimary

Risk Factors for Inter-eye Asymmetry in Keratoconus Severity

NCT07461129Active Not RecruitingPrimary

Electrophysiological Changes in Cases of Different Stages of Keratoconus

NCT07426029Not ApplicableCompletedPrimary

Effectiveness and Safety of Corneal Collagen Cross Linking After Induction of Stromal Emphysema in Keratoconus

NCT04598932Enrolling By InvitationPrimary

Corneal Biomechanical Analysis Using Brillouin Microscopy

NCT07400952Phase 2RecruitingPrimary

Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

NCT07388069Phase 1Enrolling By InvitationPrimary

Study of TN-001 Topical Eyedrops for Keratoconus

NCT07135167Phase 3Recruiting

Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

NCT07124910Phase 3RecruitingPrimary

Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases

NCT07372911Not ApplicableRecruitingPrimary

PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus

NCT06451718Not ApplicableRecruitingPrimary

First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus

NCT04741230Not ApplicableRecruitingPrimary

Investigator Initiated, Prospective Study of Xenia Corneal Lenticule

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