Assesment of Multiomics Profiles in Health and Disease.

NCT04427163 | Recruiting

• 1 other identifier: 302
• Study Type: observational
• Target: 1,100
• Locations: 1 country
• Sites: 1

Brief Summary

This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.

Conditions

Genetic Predisposition to Disease

Keywords

genomic profile; disease phenotype; proteomic profile; metabolomic profile; transcriptomic profile

Outcome Measures

Primary Outcomes (2)

• Whole Genome (Exom) Sequencing of the Healthy Volunteers - establishment of the HEALTHY VOLUNTEER REFERENCE GENOME (min. 1000 individuals)

  Establishment of the Healthy Volunteers Whole Genome (Exom) Reference Database typical for the population of the Czech Republic/Central Europe.

  72 months

• Whole Genome (Exom) Sequencing of the patient groups with different diseases and their comparison to the HEALTHY VOLUNTEER REFERENCE GENOME

  Whole Genome (Exom) Sequencing of the patient populations presenting various diseases. Based on the comparison with the HEALTHY VOLUNTEER REFERENCE GENOME - determination of various genetic polymorphisms (single nucleotide polymorphisms, insertions, deletions, inversions, copy-number variations etc.) and giving these into correlation with disease phenotypes.

  72 months

Secondary Outcomes (1)

• Evaluation of the correlation with the disease phenotype

  72 months

Study Arms (1)

Genomic, transcriptomic, proteomic, metabolomic profiles

Determination of genomic, transcriptomic, proteomic, metabolomic profiles in subjects.

Genetic: Blood sample analysis; Other: Health status; Other: Race and ethnicity

Interventions

Blood sample analysis GENETIC

Nucleic acids sequencing, presence of proteins and metabolites.

Genomic, transcriptomic, proteomic, metabolomic profiles

Health status OTHER

Health status will be examined by a physician and subject will complete a health status questionnaire.

Genomic, transcriptomic, proteomic, metabolomic profiles

Race and ethnicity OTHER

Subject will complete race and ethnicity questionnaire to make sure subjects are from the Czech population.

Genomic, transcriptomic, proteomic, metabolomic profiles

Eligibility Criteria

• Age: 18 Years - 68 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Selection from the blood donnors from the blood transfusion department.

You may qualify if:

• age 18 - 68 years
• (for the first 1100 subjects):
• healthy volunteers without genetically dependent disease and without such a disease in a family
• healthy volunteer without the preliminary evidence of civilizational diseases such as hypertension, diabetes, autoimmune and tumor diseases or acute infectional diseases; clinically manifesting cardiovascular or pulmonary disability.
• subject without permanent of long-term medication in the time of biological sampling.

Sponsors & Collaborators

• The Institute of Molecular and Translational Medicine, Czech Republic: lead

Study Sites (1)

University Hospital Olomouc

Olomouc, Czechia

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample

MeSH Terms

Conditions

Genetic Predisposition to Disease

Interventions

Health Status; alpha-methylacyl-CoA racemase; Ethnicity

Condition Hierarchy (Ancestors)

Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Demography; Population Characteristics; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Marian Hajduch, MD, PhD.

  IMTM, Palacky University in Olomouc, Faculty of Medicine and Dentistry

  STUDY DIRECTOR

Central Study Contacts

Marian Hajduch, MD, PhD.

CONTACT

+420585632083; marian.hajduch@upol.cz

Michaela Bendova, MSc.

CONTACT

+420585632050; michaela.bendova@upol.cz

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2020
• First Posted: June 11, 2020
• Study Start: September 1, 2018
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): March 30, 2029
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)