NCT05661318

Brief Summary

This Study is designed to assess CVD incidence, prevalence, progression and related risk factors, including genetic background. It will provide an important base for all cardiovascular research activities in our centre and help in designing future studies and guide policy.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5,000

participants targeted

Target at P75+ for all trials

Timeline
349mo left

Started Jan 2018

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress23%
Jan 2018Jan 2055

Study Start

First participant enrolled

January 1, 2018

Completed
5 years until next milestone

First Submitted

Initial submission to the registry

December 14, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

December 22, 2022

Completed
28 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2050

Expected
4.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2055

Last Updated

May 29, 2024

Status Verified

May 1, 2024

Enrollment Period

33 years

First QC Date

December 14, 2022

Last Update Submit

May 24, 2024

Conditions

Genetic Predisposition to Disease

Keywords

geneticsCardiovascular risks

Outcome Measures

Primary Outcomes (1)

  • Cardiovascular risk assessment

    30 years

Study Arms (1)

BHS

Residents of Ballana from the 1,200 randomly selected households

Other: Risk assessment

Interventions

Risk assessmentOTHER

Collect clinical, laboratoary and genetics data from the participants after informed consent

BHS

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

• Residents of Ballana from the 1,200 randomly selected households

You may qualify if:

  • Residents of Ballana from the 1,200 randomly selected households
  • Participants must have a valid National ID card
  • Written informed consent

You may not qualify if:

  • Residents who are younger than 18 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Aswan Heart Centre - Magdi Yacoub Heart Foundation

Aswān, Egypt

RECRUITING

Related Publications (1)

  • Keates AK, Mocumbi AO, Ntsekhe M, Sliwa K, Stewart S. Cardiovascular disease in Africa: epidemiological profile and challenges. Nat Rev Cardiol. 2017 May;14(5):273-293. doi: 10.1038/nrcardio.2017.19. Epub 2017 Feb 23.

    PMID: 28230175BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Blood for laboratory work up \& whole genome sequencing.

MeSH Terms

Conditions

Genetic Predisposition to Disease

Interventions

Risk Assessment

Condition Hierarchy (Ancestors)

Disease SusceptibilityDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

RiskProbabilityStatistics as TopicEpidemiologic MethodsInvestigative TechniquesRisk ManagementOrganization and AdministrationHealth Services AdministrationHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationEpidemiologic MeasurementsPublic HealthEnvironment and Public Health

Study Officials

  • Magdi H Yacoub, FRS OM

    Imperial College London, and Magdi Yacoub Heart Foundation

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yasmine Aguib, PhD

CONTACT

+201092036368yasmine.aguib@aswanheartcentre.com

Ahmed Elguindy, MD

CONTACT

+201001615151ahmed.elguindy@aswanheartcentre.com

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
PROSPECTIVE
Target Duration
30 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 14, 2022

First Posted

December 22, 2022

Study Start

January 1, 2018

Primary Completion (Estimated)

December 31, 2050

Study Completion (Estimated)

January 31, 2055

Last Updated

May 29, 2024

Record last verified: 2024-05

Locations

EG(1)