NCT04364061

Brief Summary

High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2020

Completed
20 days until next milestone

First Submitted

Initial submission to the registry

April 21, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 27, 2020

Completed
Last Updated

April 28, 2020

Status Verified

April 1, 2020

Enrollment Period

5 months

First QC Date

April 21, 2020

Last Update Submit

April 26, 2020

Conditions

OverweightPostmenopausal

Keywords

Exercise ModalitiesPostmenopausal womenHigh-intensity interval exerciseCHO and FAT oxidationAppetiteEnergy intakesEnjoyment

Outcome Measures

Primary Outcomes (1)

  • Post-exercise (2 hours) CHO and FAT oxidation

    CHO and FAT oxidation were measured after each modality with indirect calorimetry during 2 hours post-exercise

    2 hours post-exercise

Secondary Outcomes (4)

  • Enjoyment

    Immediately post-exercise

  • Rate Perceive Exertion (RPE)

    During exercise (5-10-15 and 20 minutes for HIIE1 and 2 ; 9-18-27 and 35 minutes for MICE) which corresponds at 25-50-75 and 100% of bout completion.

  • Appetite

    Before, immediately post-exercise, 60 minutes and 120 minutes post-exercise

  • Energy intakes

    24 hours post-exercise

Study Arms (1)

Women with overweight or obesity

EXPERIMENTAL
Other: Moderate Intensity Continuous ExerciseOther: High-Intensity Interval Exercise (1)Other: High-Intensity Interval Exercise (2)

Interventions

Moderate Intensity Continuous ExerciseOTHER

Participant completed a moderate intensity continuous cycling exercise (MICE) during 35 min at 60-65% thPHRmax

Women with overweight or obesity
High-Intensity Interval Exercise (1)OTHER

Participant completed a high-intensity interval cycling exercise (HIIE 1) during 20min with 60 cycles of speeding up for 8s and pedaling slowly for 12s at 80-90% thPHRmax

Women with overweight or obesity
High-Intensity Interval Exercise (2)OTHER

Participant completed a high-intensity interval cycling exercise (HIIE 2) during 20min with 10 x 1-min bouts at 80-90% thPHRmax, separated by 1-min recovery bouts

Women with overweight or obesity

Eligibility Criteria

Age50 Years - 75 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • postmenopausal women (spontaneous amenorrhea for at least 12 months)
  • with overweight or obesity (BMI \> 25 kg/m2 and ≤ 40 kg/m2)

You may not qualify if:

  • medical contraindications to intense physical activity,
  • painful joints,
  • taking hormone replacement therapy,
  • taking B-blockers.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CREPS Auvergne Rhône-Alpes / Vichy

Bellerive-sur-Allier, Allier, 03321, France

Location

MeSH Terms

Conditions

Overweight

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Claire MOREL, Dr

    CREPS Auvergne Rhône-Alpes / Vichy

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Masking Details
Data collected on the volunteers will be made anonymous
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 21, 2020

First Posted

April 27, 2020

Study Start

November 1, 2019

Primary Completion

April 1, 2020

Study Completion

April 1, 2020

Last Updated

April 28, 2020

Record last verified: 2020-04

Locations

FR(1)