HIIT Versus MICT on Abdominal Fat Mass and Lipid Oxidation in Postmenopausal Women (MATISSE)

NCT03357016 | Completed

• 2 other identifiers: AU13032016-A01742-49
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Abdominal fat mass accumulation is associated with an increase of cardiovascular disease (CVD) risk. Most exercise programs designed for weight loss have focused on about 30 min several times per week of moderate intensity continuous training (MICT). Disappointingly, such exercise programs have led to either none or low fat loss. Accumulating evidence suggests that high intensity interval training (HIIT) should be an effective exercise protocol for reducing body fat of overweight individuals, especially at the abdominal level. Resistance Training (RT) is associated with increased muscle mass and strength gain in main muscles groups. Thus, RT seems to be an interesting strategy to fight against deconditioning and autonomy loss with age. Development of muscle mass enhances resting metabolism rate. Thus, RT could raise daily energy expenditure ie. substrates' oxidation including lipids. The aim of our study was to compare the effects of a 12-week moderate intensity continuous training (MICT) program with high intensity interval training (HIIT) program combined or not with a resistance training (RT) program on total abdominal and visceral fat mass and substrate utilization in postmenopausal women. It is hypothesized that HIIT compared to MICT program would result in significantly greater whole body and regional fat mass losses (abdominal and visceral) and would improve lipid oxidation at rest and during prolonged moderate exercise. It is also hypothesized that HIIT associated with RT could be the best strategy to reduce fat mass.

Conditions

Overweight; Post Menopausal Women

Keywords

interval training; abdominal fat mass; postmenopausal women; lipids oxidation

Outcome Measures

Primary Outcomes (1)

• Change from baseline abdominal fat mass (g) after 3 months of training (T3-T0/T0 x 100)

  Total abdominal fat mass will be measured in all patients using DEXA based on the methodology of Martin and Jensen (1991; L1-L2 to pubic rami) before (baseline, T0) and after 3 months of training (T3).

  Baseline T0, 3 months after protocol starting

Secondary Outcomes (11)

• Lipids oxidation evaluated by gas exchange measurements

  1 week, 3 months after protocol starting

• Visceral fat mass

  Baseline T0, 3 months after protocol starting

• Total fat mass

  Baseline T0, 3 months after protocol starting

• Fat-free mass

  Baseline T0, 3 months after protocol starting

• Plasma HbA1c

  Baseline T0, 3 months after protocol starting

Study Arms (3)

High Intensity Interval Training program (HIIT)

EXPERIMENTAL

Subjects perform three sessions of training during 12 weeks: 35 min at 50% maximal aerobic power on bicycle.

Other: Training programs

Moderate Intensity Continuous Training program (MICT)

EXPERIMENTAL

Subjects perform three sessions of training during 12 weeks: repeated cycles of sprinting for 8s and pedaling slowly for 12s (between 20 and 30 rpm) for a maximum of 60 repeats per session.

Other: Training programs

HIIT + Resistance Training program (RT)

EXPERIMENTAL

Subjects perform three sessions of training during 12 weeks: Each subject performed HIIT protocol and then a single set of 8 exercises with 1 ou 2min resting period between exercises. Each set consisted of 8-12 repetitions at about 80% maximum repetition.

Other: Training programs

Interventions

Training programs OTHER

High Intensity Interval Training program (HIIT) vs. Moderate Intensity Continuous Training program (MICT) vs. High Intensity Interval Training program + Resistance Training program (HIIT+RT)

HIIT + Resistance Training program (RT); High Intensity Interval Training program (HIIT); Moderate Intensity Continuous Training program (MICT)

Eligibility Criteria

• Age: 55 Years - 82 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Postmenopausal women (55- 82 years)
• BMI ≥ 25 and \< 40
• Able to follow an exercise protocol
• Eating behavior and physical activity stable since at least 3 month

You may not qualify if:

• Subject not able to perform exercise after medical examination
• Subject not able to perform bicycle exercise (pains)
• Chronic infection
• Use of β-blocker
• Medical treatment that could interfere with the different outcome measures
• Hormonal Replacement Therapy (HRT)
• Regular consumption of alcohol
• Refusal to sign the consent form

Sponsors & Collaborators

• Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques: lead
• CREPS Vichy Auvergne: collaborator
• University Hospital, Clermont-Ferrand: collaborator

Study Sites (1)

CREPS Vichy Auvergne

Bellerive-sur-Allier, 03321, France

Location

MeSH Terms

Conditions

Overweight

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Martine Duclos, Pr

  CHRU Gabriel Montpied Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Data collected on the volunteers will be made anonymous.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2017
• First Posted: November 29, 2017
• Study Start: February 1, 2017
• Primary Completion: June 8, 2018
• Study Completion: June 8, 2018
• Last Updated: August 10, 2018

Record last verified: 2017-12

Locations

FR (1)