A Short-term Mixed Exercise for Sarcopenic Hospitalized Aged 80+ Years

NCT04355299 | Completed

• 1 other identifier: 2019#611#
• Study Type: interventional
• Target: 121
• Locations: 0 countries
• Sites: N/A

Brief Summary

Most previous clinical trials that addressed exercise for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy. There is a notable paucity of high-quality research investigating the effects and feasibility of exercise for hospitalized or institutionalized older people, who are generally frailer and more severe in functional impairment than those living in the community. Moreover, most reported exercise programs were of long-term duration, which typically lasted 3 to 6 months with two sessions per week. It remains unclear whether short-term exercise would be effective for treating sarcopenia. Therefore, the investigators aimed to assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• The change of activities of daily living from the baseline to the end of the 2-week intervention

  Basic activities of daily living (BADL) assessed by Barthel Index. The total score for Barthel Index ranges from 0 (worst) to 100 (best) points.

  2 weeks

Secondary Outcomes (4)

• The change of gait speed

  2 weeks

• The change of handgrip strength

  2 weeks

• The change of the score of Short Physical Performance Battery

  2 weeks

• The change of the score of Timed Up and Go test

  2 weeks

Study Arms (2)

Intervention group

EXPERIMENTAL

a mixed exercise program including aerobic, balance, and resistance exercises that were personally tailored.

Behavioral: balance training; Behavioral: resistance training; Behavioral: aerobic exercise

control group

OTHER

usual care

Behavioral: usual care

Interventions

balance training BEHAVIORAL

The training to improve balance is to work on the core muscle groups that help to maintain your posture.,and increase muscular strength.

Intervention group

resistance training BEHAVIORAL

Resistance training is a form of exercise that improves muscular strength and endurance. During a resistance training workout, you move your limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.

Intervention group

aerobic exercise BEHAVIORAL

Aerobic exercise is any activity that gets your blood pumping and large muscle groups working. It's also known as cardiovascular activity.

Intervention group

usual care BEHAVIORAL

received usual care

control group

Eligibility Criteria

• Age: 80 Years - 102 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• aged ≥80 years;
• being able to ambulate (assistance was acceptable);
• being able to communicate and collaborate with the physiotherapist;
• with sarcopenia defined by the AWGS criteria ;

You may not qualify if:

• terminal illness;
• uncontrolled heart failure;
• myocardial infarction within the past three months;
• uncontrolled respiratory failure;
• bone fractures within the past three months;
• acute pulmonary embolism;
• major surgery within the past three months;
• uncontrolled arrhythmia;
• refusal to participate in this study.

Sponsors & Collaborators

• Yuxiang Liang: lead

MeSH Terms

Conditions

Sarcopenia

Interventions

Resistance Training; Exercise

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jiaojiao Jiang

  West China Hospital

  PRINCIPAL INVESTIGATOR

• Ming Yang

  West China Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Physiotherapist

Study Record Dates

• First Submitted: April 17, 2020
• First Posted: April 21, 2020
• Study Start: October 1, 2016
• Primary Completion: December 30, 2019
• Study Completion: January 1, 2020
• Last Updated: April 22, 2020

Record last verified: 2020-04