Effect of Home-Based Exercise Program in Older Adults With Sarcopenia

NCT04598464 | Completed

• 1 other identifier: IstanbulU-2018-200
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 5

Brief Summary

In the prospective, randomized, controlled multi-centre study, 100 patients who were clinically diagnosed with sarcopenia were assigned to either a home-based exercise group or the control group. The home-based exercise program was performed three days per week for 12 weeks. Before and three months after the exercise program, all the patients were evaluated.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• Change from baseline timed up and go test at 3-months

  The timed up and go test test measures the amount of time needed for a patient to stand up from a chair, walk three meters as quickly and safely as possible toward a cone, walk around it, and sit down on the chair again.

  Baseline, 3-month

Secondary Outcomes (4)

• Change from baseline Berg balance scale score at 3-months

  Baseline, 3-month

• Change from baseline 6-minute walk test (6MWT) at 3-months

  Baseline, 3-month

• Change from baseline self-reported QoL at 3-months

  Baseline, 3-month

• Change from baseline number of falls at 3-months

  Baseline, 3-month

Study Arms (2)

Exercise group

EXPERIMENTAL

The home-based training program

Other: Home based exercise

control group

NO INTERVENTION

All patients participated in a one-session educational program conducted by the investigators at each clinic.

Interventions

Home based exercise OTHER

The home-based training program included posture and stretching exercises, strengthening exercises, balance training, and a walking regimen 3 days per week for 3 months.

Exercise group

Eligibility Criteria

• Age: 65 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• community-dwelling older adult diagnosis of sarcopenia according to the clinical examination; and able to walk independently. The physical performance of patients with a SARC-F score ≥4 were tested using a gait speed test and a short physical performance battery (SPPB). The diagnosis of sarcopenia was confirmed in cases where the patient's gait speed was ≤0.8 m/s and the SPPB score was ≤8

You may not qualify if:

• having cardiovascular, pulmonary, and/or chronic diseases that may affect participation in the exercise program; impaired cognition; previous diagnosis of a neurological condition that severely affected mobility and balance; malignancy; metastatic cancer; serious vision loss or vestibular impairment

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (5)

Balikesir University Faculty of Medicine, Department of Physical Therapy and Rehabilitation

Balıkesir, Turkey (Türkiye)

Location

Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Istanbul Physical Medicine and Rehabilitation Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation

Istanbul, Turkey (Türkiye)

Location

Ege University Faculty of Medicine, Department of Physical Medicine and Rehabilitation

Izmir, Turkey (Türkiye)

Location

Related Publications (1)

• Sen EI, Eyigor S, Dikici Yagli M, Ozcete ZA, Aydin T, Kesiktas FN, Aydin FY, Vural M, Sahin N, Karan A. Effect of Home-Based Exercise Program on Physical Function and Balance in Older Adults With Sarcopenia: A Multicenter Randomized Controlled Study. J Aging Phys Act. 2021 Jul 16;29(6):1010-1017. doi: 10.1123/japa.2020-0348.

  PMID: 34271551 DERIVED

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Ayse Karan, Professor

  Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 16, 2020
• First Posted: October 22, 2020
• Study Start: March 1, 2018
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: October 22, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (5)