Sarcopenia and Combined-modality Exercise

NCT04806152 | Terminated

• 1 other identifier: UWIJAMSarc
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had been characterised as having sarcopenia.

Conditions

Sarcopenia

Keywords

exercise; training

Outcome Measures

Primary Outcomes (8)

• Functional endurance

  Distance walked in 6 minutes

  6 months

• Disability

  Lawton Instrumental Activities of Daily Living scale: minimum score = 0 (low function, dependent); maximum score = 8 (high function, independent). Lower scores indicate a worse outcome.

  6 months

• Lower extremity (LE) functional strength

  1-repetition maximum (RM) strength

  6 months

• Accelerometry

  weekly energy expenditure

  6 months

• self-selected walk speed

  speed in the timed-10-metre walk

  6 months

• Appendicular lean mass index

  dual energy x-ray absorptiometry (DEXA) measured appendicular lean mass summed and divided by height squared, expressed in kg/m2

  6 months

• Balance

  Berg balance test score: minimum score = 0, maximum score = 56. Lower values indicate worse outcome

  6 months

• Fat-free mass

  dual energy x-ray absorptiometry (DEXA) determined: fat mass subtracted from weight, expressed in kg

  6 months

Secondary Outcomes (2)

• Depression

  6 months

• Timed-up-and-go

  6 months

Study Arms (2)

Sarcopenia and combined-modality high intensity supervised exercise training

EXPERIMENTAL

Participants were given Treadmill exercise training, lower extremity progressive resistance training using a Cybex leg press machine, and a 1-hour adaptive physical activity (APA) programme in which participants were required to walk for 12 minutes through an obstacle course in which they must clear 10 cm high boards, climb 3 steps and walk sideways through hula-hoops placed on the floor all the while dual-tasking i.e. waving at strategically placed signs, conversing while walking and picking up objects. Participants also performed exercises at the parallel bars which included weight-shifting from leg to leg and half-squatting; they were also guided through seated upper- and lower-limb stretching exercises for range of motion and trunk mobility. All exercise sessions were supervised by physiotherapists. For two of the weekdays on which participants did not attend supervised training, they were asked to walk for 30 minutes at home and perform the APA exercises described above.

Other: High intensity exercise

Sarcopenia and 'usual care' unsupervised exercise

ACTIVE COMPARATOR

Participants were required to do 5-12 chair rises and also 30-minutes walking 5 days per week. Upper limb and trunk flexibility exercises were also taught.

Other: Usual care home exercise

Interventions

High intensity exercise OTHER

Supervised high-intensity combined-modality exercise was administered to participants in the exercise arm for 3 times per week for 6 months. A post-exercise recovery protein drink (31g whey-based) was given within 15 minutes after each supervised exercise session.

Sarcopenia and combined-modality high intensity supervised exercise training

Usual care home exercise OTHER

Walking 30 minutes, chair rises and flexibility exercises for trunk and upper extremities 5 days per week

Sarcopenia and 'usual care' unsupervised exercise

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• over 60 years old,
• independently ambulant, with or without an assistive device
• mentally competent to give informed consent and follow exercise instructions

You may not qualify if:

• a history of stroke with residual disability
• a diagnosis of cancer
• neuromuscular disorders
• auto-immune disorders
• dementia
• severe arthritis rendering participation in an exercise programme difficult
• unstable cardiovascular disease which renders exercise unsafe

Sponsors & Collaborators

• The University of The West Indies: lead

Study Sites (1)

UWI Solutions for Developing Countries (SODECO)

Kingston, KSA, JMAKN04, Jamaica

Location

MeSH Terms

Conditions

Sarcopenia; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Terrence Forrester, PhD

  UWI Solutions for Developing Countries

  PRINCIPAL INVESTIGATOR

• Michael Boyne, MD

  UWI Department of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2021
• First Posted: March 19, 2021
• Study Start: May 2, 2017
• Primary Completion: March 20, 2020
• Study Completion: March 20, 2020
• Last Updated: March 19, 2021

Record last verified: 2021-03

Locations

JA (1)