Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function

NCT03907592 | Completed

• 1 other identifier: DSRiK/10/2017
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of the current research project is to explore whether nutritional supplementation and resistance training might be combined to produce synergistic effects in the prevention of muscle loss during aging. A secondary aim of this project is to investigate the effects of carnitine with leucine supplementation, in comparison to carnitine supplementation alone, on muscle strength and body composition. The hypothesis is that resistance training combined with nutritional supplementation have a more beneficial effect than resistance training alone in the prevention of muscle loss during aging. Leucine stimulates carnitine transport into the muscle cells, which improve mitochondrial capacity. Modification in energetic of skeletal muscle affects the body composition and muscle performance.

Conditions

Sarcopenia

Keywords

L-Carnitine; Resistance training; Magnetic resonance imaging; Muscle function; Aging; Leucine

Outcome Measures

Primary Outcomes (1)

• Volumetric changes in knee extensor muscle

  Volumetric examination of cross section area (CSA) of knee extensor muscles determined by a 1.5 T MRI scanner.

  Values at baseline will be compared to values recorded at 12 and at 24 weeks after supplementation and training procedure.

Secondary Outcomes (2)

• Changes in the strength of muscle knee extensor

  Values at baseline will be compared to values recorded at 12 and at 24 weeks after supplementation and training procedure.

• Changes in Lean Body Mass

  Values at baseline will be compared to values recorded at 12 and at 24 weeks after supplementation and training procedure.

Study Arms (3)

L-carnitine Group

EXPERIMENTAL

Group participated in the training protocol and supplemented by 1000 mg L-carnitine-L-tartrate in combination with 3000 mg L-leucine per day throughout 24 weeks.

Dietary Supplement: L-carnitine supplementation; Procedure: Resistance training

Leucine Group

EXPERIMENTAL

Group participated in the training protocol and supplemented by 4000mg of L-leucine per day throughout 24 weeks.

Dietary Supplement: Leucine supplementation; Procedure: Resistance training

Control Group

EXPERIMENTAL

Group participated in the training protocol without any supplementation throughout 24 weeks.

Procedure: Resistance training

Interventions

L-carnitine supplementation DIETARY_SUPPLEMENT

Supplementation of 1000 mg L-carnitine-L-tartrate in combination with 3000 mg L-leucine per day throughout the study period.

L-carnitine Group

Leucine supplementation DIETARY_SUPPLEMENT

Supplementation of 4000 mg L-leucine per day throughout the study period.

Leucine Group

Resistance training PROCEDURE

Resistance training at the gym, twice a week for 24 weeks (48 training units in total).

Control Group; L-carnitine Group; Leucine Group

Eligibility Criteria

• Age: 60 Years - 72 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged-matched, no chronic disease, doctor's note about the lack of restrictions to perform resistance exercises

You may not qualify if:

• diabetes, liver, heart and renal diseases, gastric problems, as well as using the vitamin supplements

Sponsors & Collaborators

• Gdansk University of Physical Education and Sport: lead
• Medical University of Gdansk: collaborator
• National Science Centre, Poland: collaborator

Study Sites (1)

University of Physical Education and Sport

Gdansk, Pomeranian Voivodeship, 80-336, Poland

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Robert A Olek, PhD

  Gdansk University of Physical Education and Sport

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 6, 2019
• First Posted: April 9, 2019
• Study Start: September 1, 2017
• Primary Completion: July 7, 2018
• Study Completion: July 7, 2018
• Last Updated: April 10, 2019

Record last verified: 2019-04

Locations

PL (1)