Non-surgical Peridontal Treatment on Cardiovascular Risk Markers
Effect of Non-surgical Peridontal Treatment on Cardiovascular Risk Markers in Patients With Severe Chronic Periodontitis
1 other identifier
interventional
80
0 countries
N/A
Brief Summary
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2015
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2017
CompletedFirst Submitted
Initial submission to the registry
March 7, 2018
CompletedFirst Posted
Study publicly available on registry
September 7, 2020
CompletedSeptember 7, 2020
September 1, 2020
6 months
March 7, 2018
September 1, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Asymmetric dimethylarginine (ADMA)
Serum Concentration (pg/mL)
At the 3rd months after non-surgical periodontal treatment
Endothelial nitric oxide synthase (eNOS)
Serum Concentration (pg/mL)
At the 3rd months after non-surgical periodontal treatment
Homocysteine (Hcy)
Serum Concentration (nmol/mL)
At the 3rd months after non-surgical periodontal treatment
Monocyte chemoattractant protein-1 (MCP-1)
Serum Concentration (ng/mL)
At the 3rd months after non-surgical periodontal treatment
Secondary Outcomes (1)
Clinical periodontal parameter
At the 3rd months after non-surgical periodontal treatment
Study Arms (1)
Non-surgical peridontal treatment
OTHERPatients with chronic periodontitis received non-surgical periodontal treatment, including scaling and root planing and polishing within 14 days under local anesthesia with manual and ultrasonic devices and standardized oral hygiene instructions including methods of tooth-brushing and interdental cleaning were also given to each one. A professional supragingival plaque control was applied on a regular basis every month.
Interventions
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of severe chronic periodontitis
- Clinical diagnosis of periodontal health
You may not qualify if:
- Systemic diseases such as diabetes, cardiovascular disease
- Periodontal treatment within the previous year
- Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months
- Pregnant or lactating
- Consumed alcohol
- Smoker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
March 7, 2018
First Posted
September 7, 2020
Study Start
August 1, 2015
Primary Completion
February 1, 2016
Study Completion
August 1, 2017
Last Updated
September 7, 2020
Record last verified: 2020-09