Caffeine Increases Maximal Fat Oxidation During Exercise in Endurance-trained Men: is There a Diurnal Variation

NCT04320446 | Completed

• 1 other identifier: Nº 507/CEIH/2018
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Maximal fat oxidation during exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) has been recognized as potential determinants of endurance performance. The purpose of this study was to determine the possible interaction between the effects of diurnal variation (morning vs. afternoon) and caffeine ingestion on MFO, Fatmax and VO2 max in endurance-trained men. Specifically, the investigators sought to elucidate whether the stimulant actions of caffeine could reverse the decrements of MFO and Fatmax observed in the morning.

Conditions

Energy Metabolism; Athletic Performance

Outcome Measures

Primary Outcomes (1)

• MFO

  Maximal fat oxidation during exercise

  Through study completion, an average of 1 month

Secondary Outcomes (2)

• FATmax

  Through study completion, an average of 1 month

• VO2max

  Through study completion, an average of 1 month

Study Arms (2)

Caffeine

EXPERIMENTAL

A dose of 3 mg/kg of caffeine (i.e. a vegetable extraction from green coffee beans, Harrison Sport Nutrition®, Spain) was ingested before the beginning of each test.

Behavioral: Test in the morning; Behavioral: Test in the afternoon

Placebo

PLACEBO COMPARATOR

A dose of 3 mg/kg of placebo (i.e. 100% purity microcrystalline cellulose, Acofarma, Spain) was ingested before the beginning of each test.

Behavioral: Test in the morning; Behavioral: Test in the afternoon

Interventions

Test in the morning BEHAVIORAL

The exercise test was performed between 8 a.m and 11 a.m

Also known as: MFO-morning, Fatmax-morning, and VO2max-morning

Caffeine; Placebo

Test in the afternoon BEHAVIORAL

The exercise test was performed between 5 p.m. and 8 p.m.a

Also known as: (MFO-afternoon, Fatmax-afternoon, and VO2max-afternoon

Caffeine; Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Having a body mass index (BMI) ranged from 18.5 to 28 kg/m2
• not suffering any specific disease which can be aggravated by physical exercise
• having previous experience in endurance training (i.e. self-reporting at least 2 years of cycling or running training including more than 3 training sessions/week).

You may not qualify if:

• Being smoker
• Taking medication or drugs
• Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
• Are deemed unsuitable by the investigator for any other reason, that prevent data collection.

Sponsors & Collaborators

• Universidad de Granada: lead

Study Sites (1)

Instituto Mixto Universitario Deporte Salud

Granada, 18016, Spain

Location

Related Publications (1)

• Ramirez-Maldonado M, Jurado-Fasoli L, Del Coso J, R Ruiz J, Amaro-Gahete FJ. Caffeine increases maximal fat oxidation during a graded exercise test: is there a diurnal variation? J Int Soc Sports Nutr. 2021 Jan 7;18(1):5. doi: 10.1186/s12970-020-00400-6.

  PMID: 33413459 DERIVED

Study Officials

• Jonatan Ruiz Ruiz, Dr.

  Universidad de Granada

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: March 19, 2020
• First Posted: March 25, 2020
• Study Start: June 1, 2019
• Primary Completion: November 30, 2019
• Study Completion: November 30, 2019
• Last Updated: March 25, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)