The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women

NCT04302038 | Completed

• 1 other identifier: HIREB 4969
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effects of potato protein on muscle protein synthesis over a short-term (a few hours after eating) and longer term (after two weeks of unilateral resistance exercise). Young women will be randomized to received potato protein supplementation or placebo in addition to their usual diet. Muscle biopsies will be taken and the participants will drink doubly labelled water to allow for the measurement of protein synthesis over time.

Conditions

Muscle Protein Synthesis

Keywords

Potato Protein; Muscle protein synthesis; Young women

Outcome Measures

Primary Outcomes (1)

• Muscle protein synthesis

  Myofibrillar protein synthesis via measurement of deuterated (doubly) labeled water

  17 days

Secondary Outcomes (1)

• Protein expression

  17 days

Study Arms (2)

Potato protein

EXPERIMENTAL

Participants will be provided with 25 g of potato protein twice per day in addition to a diet set at the recommended daily allowance. Total protein intake for this group will be 1.6 g/kg/day

Dietary Supplement: Protein

Control group

PLACEBO COMPARATOR

This group will consume protein from food sources set at 0.8 /kg/day including 2 pudding placebo cups per day.

Dietary Supplement: Placebo control

Interventions

Protein DIETARY_SUPPLEMENT

Additional daily protein provided by potato protein.

Potato protein

Placebo control DIETARY_SUPPLEMENT

No additional dietary protein (outside of 0.8 g/kg/day as provided by diet)

Control group

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• meet the age requirements
• Female sex

You may not qualify if:

• Significant loss or gain of body mass in the past 6 months (\>2 kg)
• Regular use of: non-steroidal anti-inflammatory drugs
• History of chronic disease
• Current or recently active or remised cancer
• Infectious disease; and/or gastrointestinal disease
• Consuming a vegetarian or vegan diet = Any condition or injury that would preclude them from participating in resistance exercise

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

Ivor Wynne Centre

Hamilton, Ca-on, L8S 4K1, Canada

Location

MeSH Terms

Interventions

Proteins

Intervention Hierarchy (Ancestors)

Amino Acids, Peptides, and Proteins

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Potato protein will be provided pre-mixed into prepared pudding. The control group will receive pudding without protein.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Parallel group, single blind, randomized controlled trial

Study Record Dates

• First Submitted: March 6, 2020
• First Posted: March 10, 2020
• Study Start: November 1, 2018
• Primary Completion: June 6, 2019
• Study Completion: June 6, 2019
• Last Updated: March 10, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)