Effect of Protein Quality During Overreaching in Trained Cyclists

NCT03994198 | Completed

• 1 other identifier: HIREB 3036
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

Athletes frequently undertake periods of intensified training commonly referred to as "overreaching." These training periods acutely decrease performance, with the expectation that performance will rebound and improve after a short recovery. Yet, overreaching does not always improve performance and may be a precursor to overtraining syndrome, a long-term decrement in performance. A nutritional intervention focused on the adoption of 'best practices' for protein feeding (optimal timing, dose, and quality) could help reduce the stress of overreaching, reduce the likelihood of developing overtraining syndrome, and augment adaptations to intensified exercise. While the nutrition study is our main interest, the investigators first want to validate the measurement of exercise performance. Accordingly, this project consists of two related studies: (1) the assessment of short time trials for reliability and validity; and (2) the assessment of optimal protein feeding to decrease the stress of overreaching and improve outcomes following training.

Conditions

Muscle Protein Synthesis

Outcome Measures

Primary Outcomes (2)

• Rate of myofibrillar muscle protein synthesis

  Rate of myofibrillar and protein synthesis (%/day)

  12 days

• Rate of Sarcoplasmic muscle protein synthesis

  Rate of sarcoplasmic muscle protein synthesis (%/day)

  12 days

Secondary Outcomes (5)

• Plasma amino acids

  1 x 1 hour

• Sleep efficiency (%)

  12 days

• Sleep fragmentation

  12 days

• Wake after sleep onset (WASO) in minutes

  12 days

• Total sleep time (min)

  12 days

Study Arms (2)

Alpha-lactalbumin

EXPERIMENTAL

Participants will consume 60 g of alphalactalbumin (fraction of whey protein) for 3 training days.

Dietary Supplement: Alpha-lactalbumin

Collagen peptides

ACTIVE COMPARATOR

Participants will consume 60 g of collagen peptides for 3 training days.

Dietary Supplement: Collagen peptides

Interventions

Alpha-lactalbumin DIETARY_SUPPLEMENT

A protein fraction of whey protein, higher in tryptophan

Alpha-lactalbumin

Collagen peptides DIETARY_SUPPLEMENT

Collagen peptides from bovine sources

Collagen peptides

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• non-smokers
• non-diabetic
• Participants had to be training regularly (performing aerobic exercise at least 4 times per week, including regular cycling exercise)
• Generally healthy

You may not qualify if:

• consuming excessive alcohol (\>21 units per week)
• use of an investigational drug or nutraceutical in the previous 30 days
• dairy allergy
• history of significant loss or gain of body mass in the past 6 months (\>2kg)
• regular use of non-steroidal anti-inflammatory drugs
• infectious disease, and/or the presence of any relevant disease (e.g., gastrointestinal, cardiovascular, neuromuscular, etc.).

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

Ivor Wynne Centre

Hamilton, Ontario, L8S 4L8, Canada

Location

MeSH Terms

Interventions

Lactalbumin

Intervention Hierarchy (Ancestors)

Albumins; Proteins; Amino Acids, Peptides, and Proteins; Whey Proteins; Milk Proteins; Animal Proteins, Dietary; Dietary Proteins

Study Officials

• Stuart Phillips, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Participants and the investigators will be blinded the the supplement type, only the LPI will have the codes to decipher the supplement type. Supplements are referred to as A and B.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Randomized cross-over design

Study Record Dates

• First Submitted: June 19, 2019
• First Posted: June 21, 2019
• Study Start: November 1, 2017
• Primary Completion: April 1, 2018
• Study Completion: August 30, 2018
• Last Updated: June 21, 2019

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)