Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response

NCT04894747 | Completed

• 1 other identifier: 200325_B_04UOE
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response. Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

Conditions

Muscle Protein Synthesis

Outcome Measures

Primary Outcomes (1)

• Muscle protein synthesis

  The rate of synthesis of new muscle protein (Fractional synthetic rate %/h)

  8.5 hours

Secondary Outcomes (4)

• Plasma amino acid kinetics

  8.5 hours

• Serum insulin concentrations

  8.5 hours

• Translocation of mTOR via immunohistochemistry

  8.5 hours

• mTOR phosphorylation via ATP kinase assay

  8.5 hours

Study Arms (3)

Mycoprotein

EXPERIMENTAL

Bolus ingestion of mycoprotein providing 25g of protein.

Dietary Supplement: Bolus ingestion of protein

Pea protein

EXPERIMENTAL

Bolus ingestion of pea protein providing 25g of protein.

Dietary Supplement: Bolus ingestion of protein

Mycoprotein/pea protein dry blend

EXPERIMENTAL

Bolus ingestion of mycoprotein/pea protein dry blend providing 25g of protein.

Dietary Supplement: Bolus ingestion of protein

Interventions

Bolus ingestion of protein DIETARY_SUPPLEMENT

Ingestion of 25g of protein

Also known as: Protein ingestion

Mycoprotein; Mycoprotein/pea protein dry blend; Pea protein

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI between 18 and 30
• Resistance trained

You may not qualify if:

• Any metabolic impairment
• Smoking
• Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
• A personal family history of epilepsy, seizures or schizophrenia.
• Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
• Any motor disorder.

Sponsors & Collaborators

• University of Exeter: lead
• Quorn: collaborator

Study Sites (1)

University of Exeter

Exeter, United Kingdom

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2021
• First Posted: May 20, 2021
• Study Start: May 1, 2021
• Primary Completion: June 15, 2022
• Study Completion: June 15, 2022
• Last Updated: March 22, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)