NCT04293848

Brief Summary

The goal of the planned Randomized Control Trial is to explore the effect of vibroacoustic therapy on acute stress of university students. The theoretical framework of the study is based on biopsychosocial model of stress and multimodal approach to measurement. The trial is designed as single-blinded, placebo-controlled, with participants individually randomized into two parallel-groups, including equal randomization and blocked allocation of participants. 420 participants are all full-time university students (18-30 years) and will be divided into two groups: an experimental group (receiving low vibrations combined with music) and a control group (only music without low-frequency sounds). For both groups acute stress response will be measured by spectral analysis of heart rate variability (HRV SA), galvanic skin response (GSR), salivary cortisol, standardized psychological questionnaires - visual analogue scales for stress (VAS-stress) and Perceived Stress Scales-10, Czech version (PSS-10). It is expected that the experimental group will demonstrate a lower level of stress response that will be measured by higher activity of parasympathetic activity, lower level of skin resistance, lower level of salivary cortisol and lower subjective perception of stress. If vibroacoustic therapy turns out to be effective, it can be viewed as safe, student-friendly and inexpensive prevention of stress-related health problems and promote the health of students in the course of university education.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
420

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 24, 2020

Completed
1 month until next milestone

First Posted

Study publicly available on registry

March 3, 2020

Completed
1.2 years until next milestone

Study Start

First participant enrolled

June 2, 2021

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2022

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2022

Completed
Last Updated

June 4, 2021

Status Verified

June 1, 2021

Enrollment Period

1.3 years

First QC Date

January 24, 2020

Last Update Submit

June 2, 2021

Conditions

Keywords

vibroacoustic therapy

Outcome Measures

Primary Outcomes (4)

  • subjective stress perception

    Subjective stress perception measured by Visual Analogue Scales for Stress and Perceived Stress Scales-10, Czech version.

    1 day

  • Spectral analysis of heart rate variability

    Spectral analysis of heart rate variability to measure the response of autonomous nervous system response measured by VLV Lab.

    1 day

  • Galvanic skin response

    Galvanic skin response to measure the response of autonomous nervous system response measured by VLV Lab.

    1 day

  • Salivary cortisol

    Salivary cortisol to measure the level of cortisol by Salivette Cortisol.

    1 day

Study Arms (2)

music with low-sinusoidal sound (vibrations)

EXPERIMENTAL

Participants will listen to music and low-sinusoidal sound (vibroacoustic therapy).

Other: Vibroacoustic therapy

Control Group

PLACEBO COMPARATOR

Participants will listen to music alone.

Other: Only music (no vibrations)

Interventions

listening to low-frequency sound of 40 Hz with biorhythmic sequential modulation combined to music

Also known as: music with low-frequency sound treatment
music with low-sinusoidal sound (vibrations)

listening to music, no vibrations

Control Group

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • participants want to voluntarily participate in the study,
  • they are 18-30 years old,
  • they are of Czech or Slovak nationality,
  • full-time students.

You may not qualify if:

  • psychiatric diagnosis,
  • neurologic disease (e.g. epilepsy, cerebral palsy) or any known contraindication of vibro-acoustic therapy such as muscle hypotonia, angina pectoris, psychotic or acute post-traumatic and bleeding,
  • post-traumatic stress disorder,
  • perceived pain,
  • persons after sleep deprivation,
  • substance abuse (caffeine, nicotine) on the day of experiment and in case of strong addictive substances (alcohol, drugs) 1 day before the experiment,
  • increased physical activity on the day before the experiment,
  • menstruation on the day of the experiment,
  • moderate to high food intake on the day of the experiment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Education, Palacký University Olomouc

Olomouc, 79900, Czechia

RECRUITING

MeSH Terms

Conditions

Stress, Psychological

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehavior

Study Officials

  • Jiri Kantor, PhD

    Faculty of Education, Palacky University, Olomouc, Czech Republic

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jiri Kantor, PhD

CONTACT

Zdenek Vilimek, MA

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: Sequentially numbered, opaque, sealed envelopes will be used as a mechanism for allocation concealment. The allocation sequence will be generated on a remote workplace by a specialist not participating on enrollment and assigning participants to intervention.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 24, 2020

First Posted

March 3, 2020

Study Start

June 2, 2021

Primary Completion

September 30, 2022

Study Completion

December 30, 2022

Last Updated

June 4, 2021

Record last verified: 2021-06

Data Sharing

IPD Sharing
Will share

Only a dean and dean-deputy (as trial investigators) will be allowed an access to the full dataset before their publication based on a formal request.

Shared Documents
STUDY PROTOCOL
Time Frame
From July 2021 - on

Locations