The UHSM Cardiovascular Magnetic Resonance Study
UHSM CMR
The University Hospital of South Manchester Cardiovascular Magnetic Resonance Study
2 other identifiers
observational
10,000
1 country
1
Brief Summary
This study aims to investigate the diagnostic and prognostic utility of cardiovascular magnetic resonance (CMR) imaging in a large cohort of unselected patients who are undergoing CMR scanning for clinical indications (i.e. suspected/confirmed cardiovascular disease). CMR indices will be related to the presence and severity of cardiovascular disease and other markers of cardiovascular and health status.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2015
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 22, 2014
CompletedFirst Posted
Study publicly available on registry
December 29, 2014
CompletedStudy Start
First participant enrolled
January 5, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2029
September 29, 2025
September 1, 2025
14.9 years
December 22, 2014
September 26, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
All cause mortality
10 years with planned interim analyses
Secondary Outcomes (4)
Cardiovascular death
10 years with planned interim analyses
Hospitalisation for heart failure
10 years with planned interim analyses
Development of cardiovascular disease
10 years with planned interim analyses
Development of complications of cardiovascular disease
10 years with planned interim analyses
Eligibility Criteria
Patients undergoing clinically indicated CMR scanning (i.e. patients with suspected or confirmed cardiovascular disease)
You may qualify if:
- Any adult patient undergoing clinically indicated CMR scanning at the UHSM CMR Unit.
You may not qualify if:
- Age \< 18 years, imprisonment, inability to provide informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital of South Manchester
Manchester, Greater Manchester, M23 9LT, United Kingdom
Related Publications (2)
Bradley J, Schelbert EB, Bonnett LJ, Lewis GA, Lagan J, Orsborne C, Brown PF, Black N, Naish JH, Williams SG, McDonagh T, Schmitt M, Miller CA. Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation. Heart. 2024 Jan 10;110(3):195-201. doi: 10.1136/heartjnl-2023-322857.
PMID: 37567614DERIVEDDi Marco A, Brown PF, Bradley J, Nucifora G, Anguera I, Miller CA, Schmitt M. Extracellular volume fraction improves risk-stratification for ventricular arrhythmias and sudden death in non-ischaemic cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2023 Mar 21;24(4):512-521. doi: 10.1093/ehjci/jeac142.
PMID: 35877070DERIVED
Biospecimen
Peripheral blood sampling will be performed on the same day as CMR scanning
MeSH Terms
Conditions
Study Officials
- PRINCIPAL INVESTIGATOR
Christopher A Miller, MBChB, PhD
University Hospital of South Manchester
- PRINCIPAL INVESTIGATOR
Matthias Schmitt, MD, PhD
University Hospital of South Manchester
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 22, 2014
First Posted
December 29, 2014
Study Start
January 5, 2015
Primary Completion (Estimated)
December 1, 2029
Study Completion (Estimated)
December 1, 2029
Last Updated
September 29, 2025
Record last verified: 2025-09