Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia

NCT04241081 | Unknown

• 1 other identifier: 2019-10-0091
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Investigating the effects of interrupting various lengths of prolonged sitting with bike sprints on post prandial lipemia the next day. We will conduct three trials, one control, one with two-hour sitting intervals (total of 4 bouts of bike sprints) and one with 6-hour sitting intervals I total of two bouts of bike sprints). A milkshake high fat tolerance test will be conducted the next day and whole body fat oxidation as well as triglyceride area under the curve will be measured every hour for the duration of the 6-hour test.

Conditions

Sedentary Behavior; Hypertriglyceridemia

Outcome Measures

Primary Outcomes (1)

• Triglyceride area under the curve

  Blood measurements baseline and every hour during a high fat tolerance test.

  6 hour long high fat tolerance test

Secondary Outcomes (1)

• Whole body fat oxidation

  10 min, baseline, 2 hours post ingestion of shake, 4 hours, 6 hours.

Study Arms (3)

Control group-no exercise

NO INTERVENTION

A no-exercise control. Must maintain \<4,500 steps per day for 3 consecutive days followed by a high fat tolerance test on day 4.

Exercise intervention 1

EXPERIMENTAL

Two consecutive days of \<4,500 steps per day followed by an intervention day on day 3. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 2 hours. Participants must aim to maintain \<2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.

Behavioral: Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia

Exercise intervention 2

EXPERIMENTAL

Two consecutive days of \<4,500 steps per day followed by an intervention day. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 6 hours. Participants must aim to maintain \<2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.

Behavioral: Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia

Interventions

Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia BEHAVIORAL

This is a behavioral intervention designed to determine the effect of breaking up prolonged bouts of sitting every 2 hours and every 6 hours with 5 sets of 4 second bouts of maximum effort bicycle ergometer accelerations compared to sitting alone on the blood triglyceride response and whole body fat oxidation after a high fat meal.

Exercise intervention 1; Exercise intervention 2

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Inactive or recreational healthy adults aged 18-65 years old.

You may not qualify if:

• Lactose intolerance, cardiovascular or metabolic diagnoses, medications for cardiovascular or metabolic diagnoses, orthopedic issues barring cycling.

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

University of Texas, Austin

Austin, Texas, 78705, United States

Location

MeSH Terms

Conditions

Sedentary Behavior; Hypertriglyceridemia

Condition Hierarchy (Ancestors)

Behavior; Hyperlipidemias; Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Rebecca braden, BS

CONTACT

4422156656; rebecca.braden@utexas.edu

Edward Coyle, PhD

CONTACT

512 471 8596; coyle@austin.utexas.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2020
• First Posted: January 27, 2020
• Study Start: January 1, 2020
• Primary Completion: May 1, 2020
• Study Completion: May 1, 2020
• Last Updated: January 27, 2020

Record last verified: 2020-01

Locations

US (1)