The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test

NCT04195165 | Unknown DMC

• 1 other identifier: 2019-08-0011
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that cycling for 1 hour of exercise at 65% peak oxygen consumption (VO2peak) after sitting \>13 hr/day (SIT+EX) will not be different in postprandial plasma insulin responses compared to the control of only sitting (SIT). Furthermore, the investigators hypothesize that the SIT and SIT+EX groups will have a less favorble insulin response compared to the physically active group after performing the same 1-hour exercise bout (ACTIVE+EX).

Conditions

Sedentary Behavior; Insulin Sensitivity; Sedentary Lifestyle

Keywords

glucose tolerance; exercise; insulin sensitivity

Outcome Measures

Primary Outcomes (1)

• Insulin sensitivity

  The investigators will measure glucose and insulin levels from data collected during the oral glucose tolerance test.

  Up to 4 weeks after data completion

Study Arms (3)

SIT

EXPERIMENTAL

Subject will be asked to take \<3,000 steps for two intervention days prior to an oral glucose tolerance test on the third day.

Behavioral: SIT

SIT+EX

EXPERIMENTAL

Subject will be asked to take \<3,000 steps for two intervention days. On the evening of the second intervention day, the subject will cycle for one hour at 65% of VO2peak. The subject will undergo an oral glucose tolerance test on the morning of the third day.

Behavioral: SIT; Behavioral: EX

ACTIVE+EX

EXPERIMENTAL

Subject will be asked to take \>10,000 steps for two intervention days. On the evening of the second intervention day, the subject will cycle for one hour at 65% of VO2peak. The subject will undergo an oral glucose tolerance test on the morning of the third day.

Behavioral: ACTIVE; Behavioral: EX

Interventions

SIT BEHAVIORAL

For the SIT and SIT+EX conditions, the subject will be asked to take \<3,000 steps. This is meant to achieve \~12-13 hours of sitting per day, are the investigators are measuring the effect of inactivity and exercise on insulin sensitivity.

SIT; SIT+EX

ACTIVE BEHAVIORAL

For the ACTIVE+EX condition, the subject will be asked to take \>10,000 steps for the two intervention days. This is meant to simulate an active lifestyle.

ACTIVE+EX

EX BEHAVIORAL

The SIT+EX and ACTIVE+EX conditions will include an exercise bout on the evening of the second intervention day, and have the oral glucose tolerance test the next morning.

Also known as: Exercise

ACTIVE+EX; SIT+EX

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, untrained/recreationally active men and women.
• Women must not be pregnant or post-menopausal.

You may not qualify if:

• Heart problems or coronary artery disease
• Hypertension
• Lung or respiratory problems
• Chest pain, fainting, or heart palpitations during exercise, or told to give up sports because of health problems.

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

University of Texas at Austin

Austin, Texas, 78712, United States

RECRUITING

MeSH Terms

Conditions

Sedentary Behavior; Insulin Resistance; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Michael B Dial

  University of Texas at Austin

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Michael B Dial

CONTACT

8018915699; Michael.dial@utexas.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Graduate Student

Study Record Dates

• First Submitted: September 24, 2019
• First Posted: December 11, 2019
• Study Start: September 23, 2019
• Primary Completion: June 30, 2020
• Study Completion: September 23, 2020
• Last Updated: December 11, 2019

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)