The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform
INSPIRE
1 other identifier
observational
1,000
1 country
1
Brief Summary
Since aging is a systemic (not organ-specific) phenomenon, the main objective of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including imaging) and digital resources that will be explored to identify robust (set of) markers of aging, age-related diseases and IC evolution. The Inspire Platform will gather data and biospecimens from subjects of different ages (from 30 years or over - no upper limit for age) and functional capacity levels (from robust to frail to disabled) over 10 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 15, 2019
CompletedStudy Start
First participant enrolled
October 16, 2019
CompletedFirst Posted
Study publicly available on registry
January 13, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 16, 2031
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 31, 2033
November 21, 2023
November 1, 2023
12 years
October 15, 2019
November 20, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Data collection of key variables and biospecimens
The main outcome of Inspire Bio-resource Research Platform for Healthy Aging is to build a comprehensive research platform gathering biological, clinical (including imaging) and digital resources that will be explored to identify robust (set of) markers of aging, age-related diseases and intrinsic capacities (cognition, mobility, nutrition, hearing and visual capacities, psychological capacity) evolution. The Inspire Platform will gather data and biospecimens from subjects of different ages (from 30 years or over - no upper limit for age) and functional capacity levels (from robust to frail to disabled) over 10 years.
through study completion, an average of 10 years
Secondary Outcomes (20)
Identification of (a set of) biomarkers of aging through the constitution of a comprehensive biobank comprising: blood, saliva, urine, nasopharyngeal swabbing, skin biopsies and surface samples, dental plaque, faeces, hair bulb.
through study completion, an average of 10 years
measure intrinsic capacity domains with questionnaire in ICOPE App (developed in collaboration with W.H.O.)
through study completion, an average of 10 years
Basic and instrumental activities of daily living.
through study completion, an average of 10 years
Mini-nutritional assessment and food frequency questionnaire.
through study completion, an average of 10 years
Lifestyle questionnaires
through study completion, an average of 10 years
- +15 more secondary outcomes
Interventions
Several follow-up visits will be undertaken during the 10-year time frame of this project. Some of these visits are not regularly scheduled and will be conditioned by the remote monitoring of intrinsic capacity (IC) and the onset of other major clinical conditions. Other visits correspond to the regularly scheduled (yearly or every two years (biannual visits), depending on the outcome measures) waves of data collection.
Eligibility Criteria
Recruitment will be stratified per 10-year age groups, oversampling older people in order to be able to investigate major clinical events (eg, declines on IC, onset of age-related diseases)
You may qualify if:
- Aged 30 years-old or over;
- Both sexes
- Affiliated to a social security scheme
You may not qualify if:
- severe disease compromising life expectancy at 5 years;
- Deprived of their liberty by administrative or judicial decision, or under guardianship
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospital, Toulouselead
- European Regional Development Fundcollaborator
Study Sites (1)
University Hospital Toulouse
Toulouse, 31059, France
Related Publications (1)
Bellelli F, Raffin J, Cesari M, Guyonnet S, Furman D, Rolland Y, Vellas B, de Souto Barreto P; IHU HealthAge INSPIRE Platform Group; IHU HealthAge Open Science group. The association of pain with intrinsic capacity and the moderating role of inflammation in France: a cross-sectional analysis of the INSPIRE-T project. Lancet Healthy Longev. 2025 Dec;6(12):100798. doi: 10.1016/j.lanhl.2025.100798. Epub 2025 Dec 5.
PMID: 41360071DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Bruno VELLAS, MD
University Hospital of Toulouse
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 15, 2019
First Posted
January 13, 2020
Study Start
October 16, 2019
Primary Completion (Estimated)
October 16, 2031
Study Completion (Estimated)
October 31, 2033
Last Updated
November 21, 2023
Record last verified: 2023-11