Ageing BIOmarker Study in Singaporeans

NCT06555978 | Active Not Recruiting

• 1 other identifier: NHG-DSRB-2019-00388
• Study Type: observational
• Target: 420
• Locations: 1 country
• Sites: 1

Brief Summary

The Ageing BIOmarker Study in Singaporeans (ABIOS) aims to understand the biological aging processes and how they affect health among people in Singapore. As people grow older, their risk of developing chronic diseases increases. This study aims to better understand the biological changes that come with age, particularly in three major ethnic groups: Chinese, Malay, and Indian adults over 21 years old. By examining a range of health indicators such as DNA methylation, inflammation, metabolism, cardiovascular health, physical function, and physical activity (i.e., molecular, physiological, and digital biomarkers of ageing), the study seeks to identify how ethnicity, lifestyle, and socioeconomic factors influence ageing. This unique study focuses on an all-Asian population, aiming to enhance our understanding of healthy aging across different ethnic groups.

Conditions

Healthy Aging; Biological Aging; Lifestyle Factors

Keywords

Aging; Biological Clocks; DNA methylation; Geroscience; Lifestyle

Outcome Measures

Primary Outcomes (1)

• blood DNA methylation

  DNA methylation ageing clock, years

  Baseline

Secondary Outcomes (18)

• Carotid-femoral Pulse Wave Velocity

  Baseline

• Handgrip strength

  Baseline

• 8-repetition maximal strength

  Baseline

• Skin autofluorescence

  Baseline

• Objective physical activity

  Baseline

Other Outcomes (14)

• Blood pressure

  Baseline

• Waist-to-hip ratio

  Baseline

• Bone mineral density

  Baseline

Study Arms (1)

Singaporean adults

Adults greater than 21 years of age living in Singapore of Chinese, Malay, or Indian ethnicity.

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults 21 years of age or greater who has lived in Singapore for at least 5 consecutive years and is of Chinese, Malay, or Indian ethnicity

You may qualify if:

• ≥21 years of age
• Chinese, Malay, or Indian and has lived in Singapore for at least 5 consecutive years
• Apparently healthy and non-smokers
• Having only 1 condition (if ≥45 and \<65 years) or any condition (if ≥65 years), and all conditions were medication-controlled (if any):
• Hypertension
• Hyperlipidemia
• Hyperglycemia
• Osteopenia/osteoporosis
• Osteoarthritis
• Type 2 diabetes

You may not qualify if:

• Body mass index (BMI) ≥30 kg/m\^2
• Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease)
• Any metal implants (excluding dental implants) in the body
• Pre-existing or history of cancer or chronic obstructive pulmonary disease (COPD)
• Pregnant women or planning pregnancy in the next 6-12 months

Sponsors & Collaborators

• National University of Singapore: lead

Study Sites (1)

Centre for Healthy Longevity at Alexandra Hospital

Singapore, 159964, Singapore

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood (serum, plasma, buffy, peripheral blood mononuclear cells), saliva (whole), and stool (whole) samples.

Study Officials

• Andrea Maier, MD, PhD

  National University of Singapore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research

Study Record Dates

• First Submitted: August 8, 2024
• First Posted: August 15, 2024
• Study Start: March 12, 2021
• Primary Completion: July 4, 2024
• Study Completion: August 31, 2025
• Last Updated: October 26, 2024

Record last verified: 2024-10

Locations

SG (1)