Study of Microbiota in Longevity County, Yongfu

NCT04210934 | Completed

• 1 other identifier: 20170307
• Study Type: observational
• Target: 160
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was explored, and the intestinal microecological balance increased with age and natural health. Longevity relationship. This study was completed using a household survey. Through routine clinical examinations and analysis of biochemical laboratory indicators, at the same time, a questionnaire for ADL(activities of daily living), cognitive function, and related elderly information was carried out on the elderly to comprehensively provide health information for each elderly. Based on the remaining stool samples and serum samples, the second-generation sequencing technology and other omics-based technologies were explored. No additional collection of human specimens and information is involved. In addition, this study also hopes to explore the transmission rules of age-related bacteria in long-lived families, and the relationship with health phenotypes such as blood sugar, blood lipids, and cognitive function. Potential impact. In summary, this study will provide data support for exploring the relationship between healthy longevity and intestinal microecological balance based on the characteristic population of the longevity hometown.

Conditions

Aging; Healthy Aging

Keywords

Microbiota; multi-omics

Outcome Measures

Primary Outcomes (1)

• Aging-related fecal microbiota annotation

  Taxonomy of bacteria(family,genus,species),Gene of bacteria

  0 week

Secondary Outcomes (1)

• interface of microbiota and other biomarkers in aging and related conditions

  0 week

Eligibility Criteria

• Age: 22 Years - 111 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The current study was based on the Longevity and Health of Aging Population in Guangxi China (LHAPGC) study conducted in Yongfu County (qualified as the longevity town by Geriatric Society of China) in 2016.The enrolled subjects do not rely on medical care and do not take antibiotics recently. They are representative of a natural healthy-aging population model .

You may qualify if:

• Obtained informed consent signed by volunteer or guardian
• Local lived for more than 50 years

You may not qualify if:

• Subjects being treated with antibiotic in 3 months
• People who cannot cooperate with completing the survey
• Severe gastrointestinal disorders

Sponsors & Collaborators

• Beijing Hospital: lead
• BGI-Shenzhen: collaborator

Biospecimen

Retention: SAMPLES WITH DNA

peripheral blood blood, 2 mL (serum) faeces, 200 mg

Study Officials

• Liang Sun, Ph.D.

  Beijing Hospital

  PRINCIPAL INVESTIGATOR

• Ze Yang, M.D.

  Beijing Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Medical Genetics

Study Record Dates

• First Submitted: December 22, 2019
• First Posted: December 26, 2019
• Study Start: May 22, 2016
• Primary Completion: May 31, 2016
• Study Completion: May 31, 2016
• Last Updated: December 27, 2019

Record last verified: 2019-12