Strawberries, Cognition, and Vascular Health

NCT04786665 | Completed

• 1 other identifier: 59650A
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to investigate the effects of strawberries on cognitive responses, motor control function, and vascular and cardiometabolic risk markers in healthy older adults.

Conditions

Aging; Healthy Aging

Keywords

Cognition; Motor control; Vascular health

Outcome Measures

Primary Outcomes (5)

• Change from baseline in processing speed (cognition) at 8 weeks

  using Pattern Comparison Processing Speed Test

  At baseline, at 8 weeks

• Change from baseline in executive function (cognition) at 8 weeks

  using Dimensional Change Card Sort Test; Flanker Inhibitory Control and Attention Test

  At baseline, at 8 weeks

• Change from baseline in working memory (cognition) at 8 weeks

  using List Sorting Working Memory Test

  At baseline, at 8 weeks

• Change from baseline in episodic memory (cognition) at 8 weeks

  using Picture Sequence Memory Test

  At baseline, at 8 weeks

• Change from baseline in working memory (cognition) at 8 weeks

  using Picture Vocabulary Test; Oral Reading Recognition Test

  At baseline, at 8 weeks

Secondary Outcomes (1)

• Change from baseline in Vascular health at 8 weeks

  At baseline, at 8 weeks

Study Arms (2)

Strawberry powder

EXPERIMENTAL

Participants consume 1 package of standard strawberry powder (26 g) daily for 8 weeks

Other: Strawberry

Placebo group

PLACEBO COMPARATOR

Participants consume 1 package of placebo powder (26 g) daily for 8 weeks

Other: Placebo group

Interventions

Strawberry OTHER

Freeze dried strawberry powder

Strawberry powder

Placebo group OTHER

Comparative placebo powder

Placebo group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Healthy men and women 65 years and older

You may not qualify if:

• stroke or myocardial infarction
• neurological disorders:
• epilepsy,
• multiple sclerosis,
• Parkinson's disease,
• stroke
• known metabolic disorders:
• liver,
• renal
• clinically diagnosed diabetes
• drug treatment for lipid reduction or hypertension,
• psychiatric medication use

Sponsors & Collaborators

• San Diego State University: lead

Study Sites (1)

Shirin Hooshmand

San Diego, California, 92182-7251, United States

Location

Related Publications (1)

• Delaney K, Tsang M, Kern M, Rayo VU, Jason N, Hong MY, Liu C, Hooshmand S. Strawberries modestly improve cognition and cardiovascular health in older adults. Nutr Metab Cardiovasc Dis. 2025 Aug;35(8):104018. doi: 10.1016/j.numecd.2025.104018. Epub 2025 Mar 18.

  PMID: 40199714 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials).

Study Record Dates

• First Submitted: March 3, 2021
• First Posted: March 8, 2021
• Study Start: October 30, 2019
• Primary Completion: February 25, 2022
• Study Completion: May 3, 2022
• Last Updated: May 5, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)