The Aerobic and Cognitive Training System
1 other identifier
interventional
74
0 countries
N/A
Brief Summary
This study will determine the effects of simultaneous exercise and cognitive training on cognitive function in healthy older adults. Specifically, this study will compare the use of a tablet-based cognitive training system while exercising with exercise alone, cognitive training alone, and a neutral control condition on cognition.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2015
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 20, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
November 20, 2017
CompletedFirst Submitted
Initial submission to the registry
October 4, 2019
CompletedFirst Posted
Study publicly available on registry
October 9, 2019
CompletedOctober 9, 2019
May 1, 2019
2.6 years
October 4, 2019
October 7, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Change from baseline in cognitive function during dual-task test at 12 weeks
Performance on serial subtraction during dual-task walking.
Baseline and 12-weeks
Secondary Outcomes (7)
Change from baseline in stride length during dual-task test
Baseline, 6 weeks, 12 weeks
Change from baseline in stride duration during dual-task test
Baseline, 6 weeks, 12 weeks
Change from baseline in stride velocity during dual-task test
Baseline, 6 weeks, 12 weeks
Change from baseline in stride length variability during dual-task test
Baseline, 6 weeks, 12 weeks
Change from baseline in stride duration variability during dual-task test
Baseline, 6 weeks, 12 weeks
- +2 more secondary outcomes
Other Outcomes (10)
Change from baseline in Wechsler Adult Intelligence Scale-IV Digit Span total score
Baseline, 6 weeks, 12 weeks
Change from baseline in Wechsler Adult Intelligence Scale-IV Coding total score
Baseline, 6 weeks, 12 weeks
Change from baseline in Wechsler Adult Intelligence Scale-IV Letter-Number Sequencing total score
Baseline, 6 weeks, 12 weeks
- +7 more other outcomes
Study Arms (4)
Simultaneous exercise and cognitive training
EXPERIMENTALParticipants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.
Exercise training
ACTIVE COMPARATORParticipants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.
Cognitive training
ACTIVE COMPARATORParticipants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.
Neutral Video
ACTIVE COMPARATORParticipants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.
Interventions
Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.
Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.
Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.
Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.
Eligibility Criteria
You may qualify if:
- Generally healthy, age 60-74, and a written statement from their primary care physician indicating that they are able to participate in the 12-week exercise program.
You may not qualify if:
- Subjects will be excluded from participating in the study if they express significant concerns about their memory or declines in other cognitive abilities, if they are not English speaking, or if they have histories of significant major neurological, psychiatric, or medical disorder or injury that would affect cognitive function.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Raichlen DA, Bharadwaj PK, Nguyen LA, Franchetti MK, Zigman EK, Solorio AR, Alexander GE. Effects of simultaneous cognitive and aerobic exercise training on dual-task walking performance in healthy older adults: results from a pilot randomized controlled trial. BMC Geriatr. 2020 Mar 2;20(1):83. doi: 10.1186/s12877-020-1484-5.
PMID: 32122325DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gene Alexander
University of Arizona
- PRINCIPAL INVESTIGATOR
David Raichlen
University of Arizona
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 4, 2019
First Posted
October 9, 2019
Study Start
May 1, 2015
Primary Completion
November 20, 2017
Study Completion
November 20, 2017
Last Updated
October 9, 2019
Record last verified: 2019-05