NCT05960331

Brief Summary

The goal of this clinical trial is to explore the benefits of autonomy supported learning in patients with Parkinson's disease. The main questions to answer are:

  • Whether autonomy supported learning can benefit motor learning in PD patients
  • Whether autonomy supported learning can enhance intrinsic motivation and/ or information processing of PD patients in learning a new task.
  • Whether autonomy supported learning can facilitate cortical excitability change after practicing a new task. Participants will be recruited into two groups (Self-control group, SC; and yoked group, YK) to learn a finger-pressing trajectory matching task
  • Participants in SC group will have choice over feedback schedule during trial practice
  • Participants in YK group will receive feedback with no-choice during trial practice Researchers will compare the retention test performance to see if autonomy supported learning will lead to better learning effect.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
72

participants targeted

Target at P75+ for not_applicable parkinson-disease

Timeline
Completed

Started Aug 2023

Typical duration for not_applicable parkinson-disease

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 17, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 25, 2023

Completed
27 days until next milestone

Study Start

First participant enrolled

August 21, 2023

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2025

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

November 18, 2025

Status Verified

November 1, 2025

Enrollment Period

1.9 years

First QC Date

July 17, 2023

Last Update Submit

November 16, 2025

Conditions

Parkinson Disease

Keywords

Parkinson's diseaseAutonomyMotor learningTranscranial magnetic stimulation

Outcome Measures

Primary Outcomes (1)

  • Performance accuracy

    Overall performance accuracy relative to the target waveform was assessed using root mean square error (RMSE), which is the mean difference between the target waveform and the participant's movement trajectory calculated over their actual movement time.

    up to day 7

Secondary Outcomes (3)

  • Intrinsic Motivation Inventory

    day 1, day 2, day 7

  • Error Estimation

    day 2, day 7

  • Cortical excitability changes

    Baseline, day 2, day 7

Study Arms (2)

Self-control group

EXPERIMENTAL

Participants will be able to choose over feedback schedule when practicing finger-pressing trajectory matching task.

Behavioral: Autonomy supported learning

Yoked group

ACTIVE COMPARATOR

Participants will receive feedback, which was determined by their counterpart in self-control group, with no-choice when practicing finger-pressing trajectory matching task.

Behavioral: Practice with predetermined feedback

Interventions

Autonomy supported learningBEHAVIORAL

The ability of learners to participate in determining their own behaviour, which is the feedback schedule regarding their practice performance in this study.

Self-control group
Practice with predetermined feedbackBEHAVIORAL

Learners practice the motor task, while the feedback is provided according to their counterpartner

Yoked group

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age above 20-years-old
  • able to follow instructions to perform the tasks (Montreal Cognitive Assessment ≥ 24)
  • no surgery and injury in upper extremities in recent 6 months

You may not qualify if:

  • other neurological disorders in addition to Parkinson's disease
  • Parkinson's disease dementia
  • symptom of severe tremor in upper extremities (score ≥ 3 in Question 15 to 18 of UPDRS-III)
  • deep brain stimulation or pacemaker implanted
  • medical history of seizure
  • a blood-relative with history of epilepsy
  • unstable medical conditions
  • pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan University Hospital

Taipei, 100229, Taiwan

RECRUITING

Related Publications (2)

  • Carter MJ, Ste-Marie DM. Not all choices are created equal: Task-relevant choices enhance motor learning compared to task-irrelevant choices. Psychon Bull Rev. 2017 Dec;24(6):1879-1888. doi: 10.3758/s13423-017-1250-7.

    PMID: 28224481RESULT

  • Chiviacowsky S, Wulf G, Lewthwaite R, Campos T. Motor learning benefits of self-controlled practice in persons with Parkinson's disease. Gait Posture. 2012 Apr;35(4):601-5. doi: 10.1016/j.gaitpost.2011.12.003. Epub 2011 Dec 30.

    PMID: 22209649RESULT

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Central Study Contacts

YA-YUN LEE, PhD

CONTACT

+886-2-33668155yayunlee@ntu.edu.tw

DE-JUN LIM, Bachelor

CONTACT

+886-9-66716146R11428011@ntu.edu.tw

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 17, 2023

First Posted

July 25, 2023

Study Start

August 21, 2023

Primary Completion

July 31, 2025

Study Completion

December 31, 2025

Last Updated

November 18, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share

Locations

TW(1)