Hemodynamic Resuscitation and Monitoring in Early Sepsis
HERMES
1 other identifier
observational
500
1 country
247
Brief Summary
"Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES Study)" involves recording of patient's medical data related to that has been collected as part of his/her routine medical care in ICU. Presently there is no data from Indian ICUs on the way patients in early sepsis are resuscitated and monitored. There may exist a wide variation in clinical practice. The investigators would like to conduct an observational study in various levels of Indian ICUs, to prospectively collect data on adult patients admitted to ICU with early sepsis in a 60-day window period. Investigator would like to study the hemodynamic resuscitation and monitoring performed in these patients. In addition, Investigator would like to identify factors associated with improved outcomes and achieving the goals of the sepsis bundles in one, three and six hours. The objectives of the study is to capture the patient characteristics and hemodynamic resuscitation and monitoring practices in patients presenting with early sepsis and hypotension to Indian ICUs Investigator plan to recruit 50 -100 centers nationwide. Each center will be asked to collect data from at least 10 patients in a maximum time window of 60 days. A convenience sample of minimum 500 patients presenting to ICU with suspected sepsis and hypotension will be taken. Each Centre will guarantee the integrity of data collection and ensure timely completion of the case record forms. Each center will select a 60 day window period for patient recruitment. The start date may be anytime any time between 1st August to 15th October 2019. Therefore, the recruitment window period will end for a respective centre, anytime between 30th September and 14th December 2019, depending on the start date. All consecutive patients in the 60-day period will be screened and those eligible will be enrolled. This is an ISCCM(Indian Society of Critical Care Medicine) Research Committee funded study. The ISCCM will fund the Principal Investigator for all expenses related software development, website hosting, secretarial assistance and miscellaneous expenses related to the conduct of the study, data analysis and publication. No funding will be given to the investigators from the various participating centers for contributing data.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2019
Typical duration for all trials
247 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 19, 2019
CompletedStudy Start
First participant enrolled
October 22, 2019
CompletedFirst Posted
Study publicly available on registry
October 29, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 31, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
January 31, 2023
CompletedOctober 24, 2022
October 1, 2022
3.3 years
October 19, 2019
October 20, 2022
Conditions
Outcome Measures
Primary Outcomes (2)
ICU Mortality
Overall ICU Mortality due to septic shock with hypotension
throughout ICU stay till discharge (up to 2 months)
Completing the elements of the one hour SSC sepsis bundle in one 1 hour
Identify factors associated with improved outcomes and fulfilling the goals of the one hour Surviving Sepsis Campaign (SSC) bundles within one, three and six hours in patients with sepsis and septic shock and to identify compliance with the one hour SSC bundle guidelines The Surviving Sepsis Campaign released an updated one-hour sepsis bundle, which combines recommendations listed in the three-hour and six-hour bundles. This includes 5 elements: 1. measuring lactate levels 2. obtaining blood cultures before administering antibiotics 3. administering broad-spectrum antibiotics 4. fluid resuscitation for hypotension or lactate level ≥ 4 mmol/L and 5. use of vasopressors for hypotensive during or after fluid resuscitation to maintain MAP ≥ 65 mm Hg
1 hour after admission upto 60 days from the study start date in respective study site (60 days)
Secondary Outcomes (3)
Hospital mortality
throughout the hospital stay till discharge in the respective study site (up to 3 months)
28-day mortality
From ICU admission to 28 days in the respective study site (up to 3 months)
Completing the elements of the one hour SSC sepsis bundle in one, three and six hours
1 hour, 3 hour and six hour after admission upto 60 days from the study start date in the respective study site (60 days )
Interventions
No Intervention
Eligibility Criteria
Adult patients presenting to ICU with suspected sepsis and hypotension
You may qualify if:
- Adult patients (≥ 18 years old)
- Presenting to ICU with suspected sepsis
- Presence of hypotension (Systolic BP ≤ 90 mmHg / Mean arterial pressure (MAP) ≤ 65mmhg or patient with Systolic BP \> 90 mmHg / MAP \>65mmHg on vasopressor.
You may not qualify if:
- Patient likely to be in shock due to reason other than sepsis (e.g. cardiogenic or hemorrhagic shock)
- Decision taken for not intubating / ventilating /aggressive resuscitation prior to ICU admission
- Patient transferred from another ICU OR another hospital (only if stay \>7 days)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tata Memorial Centrelead
- Indian Society of Critical Care Medicinecollaborator
Study Sites (247)
AIIMS Patna
Patna, Bihar, India
All india institute of medical sciences
Patna, Bihar, India
Anant Institute of Medical Sciences
Jabalpur, Madhya Pradesh, India
Breach Candy Hospital Trust
Mumbai, Maharashtra, India
Criticare Hospital and Research Institute
Nagpur, Maharashtra, India
Galaxy care hospital
Pune, Maharashtra, India
Sanjeevan Hospital
Pune, Maharashtra, India
Dayanand Medical College and Hospital
Ludhiana, Punjab, India
Eternal Hospital
Jaipur, Rajasthan, India
Kamlesh Kanwar Shekhawat
Udaipur, Rajasthan, India
Pims
Udaipur, Rajasthan, India
Sarvodaya hospital and research centre
Farīdābād, Uttar Pradesh, India
Fortune Hospital
Kanpur, Uttar Pradesh, India
Sir Sundar lal Hospital, IMS, BHU, Varanasi
Varanasi, Uttar Pradesh, India
Sir Sunderlal Hospital
Varanasi, Uttar Pradesh, India
Nayati Hospital - Trauma & Acute Care Centre
Agra, India
Purushottam das Savitri Devi Cancer center
Agra, India
Pushpanjali Hospital
Agra, India
Rainbow Hospitals
Agra, India
Saideep Healthcare and Research Pvt Ltd
Ahilyanagar, India
Narayana Multispeciality Hospital
Ahmedabad, India
Sterling hospital
Ahmedabad, India
Zydus Hospitals Ahmedabad
Ahmedabad, India
J N Medical College & Hospital
Aligarh, India
Ohm Trauma centre and critical care
Aligarh, India
Emc hospital
Amritsar, India
Fortis Escorts Hospital Amritsar
Amritsar, India
Kamalnayan Bajaj hospital
Aurangabad, India
Mgm Medical College Hospital and Medical Centre Research Institute(McRi)
Aurangabad, India
Oriion Citicare Superspeciality Hospital
Aurangabad, India
Shraddha hospital and critical care center
Aurangabad, India
Bhagwan Mahaveer Jain Hospital
Bangalore, India
Columbiaasia Referral Hospital, Yeshwantpur
Bangalore, India
Cytecare Cancer Hospital
Bangalore, India
Health care Global (HCG)
Bangalore, India
Shifaa hospital
Bangalore, India
Shri Ram Murti Smarak Institute of Medical Sciences
Bareilly, India
Geeta Hospital and research centre
Barnagar, India
Aster R V Hospital
Bengaluru, India
Manipal hospital
Bengaluru, India
Mazumdar Shaw Medical Center
Bengaluru, India
Regal Hospital
Bengaluru, India
St John's Medical College Hospital
Bengaluru, India
Vydehi Institute of Medical Sciences and Research Centre
Bengaluru, India
Apollo Hospitals
Bhubaneshwar, India
Amri hospital ICU -1
Bhubaneswar, India
AMRI Hospitals
Bhubaneswar, India
Amri Hospital
Bhubaneswar, India
Apollo Hospitals
Bhubaneswar, India
Apollo Hospital
Bhubaneswar, India
BR Life Kalinga Hispital
Bhubaneswar, India
Care Hospitals
Bhubaneswar, India
Care Hospital
Bhubaneswar, India
Gudage Hospital
Bidar, India
Apollo Hospital Icu-1
Bilāspur, India
Apollo Hospital
Bilāspur, India
Ayush Hospital
Bījāpur, India
K.M.Memorial hospital and research centre
Bokāro, India
PGIMER
Chandigarh, India
Apollo Hospitals Enterprise limited
Chennai, India
Billroth hospital
Chennai, India
Dr.Rela Institute and Medical Centre
Chennai, India
Mgm Healthcare Ltd.
Chennai, India
Sri Ramachandra Hospital
Chennai, India
Sri Ramchandra Medical Centre
Chennai, India
Kovai Medical Center Hospital and Research
Coimbatore, India
Royal Care Super Speciality Hospital
Coimbatore, India
Ashwini Hospital
Cuttack, India
Goodluck Hospital
Cuttack, India
Scb Medical College and Hospital
Cuttack, India
SCB Medical College
Cuttack, India
Paras Global Hospital
Darbhanga, India
Dharmshila Narayana Superspeciality Hospital
Delhi, India
Dr. Ram Manohar Lohia Hospital ,New Delhi
Delhi, India
Dr. Ram Manohar Lohia Hospital
Delhi, India
kailash Hospital and heart Institute
Delhi, India
Pushpawati Singhania Research Institute
Delhi, India
Sir Ganga Ram Hospital
Delhi, India
BKL Walawalkar Hospital
Dervān, India
Muthukrishnan Periasamy
Erode, India
Qrg Healthcity
Faridabad, India
Yashoda super specialty hospital, kaushambi
Ghaziabad, India
City Hospital
Gorakhpur, India
Dr.Ramesh Cardiac and Multiplicity PVT LTD
Guntur, India
GBR super speciality hospitals
Guntur, India
Lalitha Super Specialities Hospital
Guntur, India
Samistha Hospital and Research Institute
Guntur, India
Apollo Hospitals Guwahati
Guwahati, India
Apollo hospitals
Guwahati, India
Ayursundra Superspecialty hospital
Guwahati, India
Dispur Hospitals pvt Ltd
Guwahati, India
Gnrc Hospitas, Dispur
Guwahati, India
Health City
Guwahati, India
Nemcare Hospital
Guwahati, India
Medanta Medicity
Gūrgaon, India
Medanta the medicity hospital
Gūrgaon, India
Medanta the medicity
Gūrgaon, India
Narayana Super Specialty Hospital
Gūrgaon, India
VPS Medeor Hospital
Gūrgaon, India
Santhi Hospital
Hosūr, India
Aig Hospitals, Gachibowli
Hyderabad, India
Apollo Health City ICU-1
Hyderabad, India
Apollo health city
Hyderabad, India
Aware Gleneagles Global Hospital
Hyderabad, India
Care hospital and institute of medical sciences
Hyderabad, India
Care hospitals banjara
Hyderabad, India
CENTURY hospital
Hyderabad, India
Century Super Speciality Hospital
Hyderabad, India
Continental Hospitals
Hyderabad, India
Gleneagles Global Hospital
Hyderabad, India
Krishna Institute of Medical Sciences
Hyderabad, India
Rainbow childrnes hospital
Hyderabad, India
South Central Railway Hospital ICU-1
Hyderabad, India
South Central Railway Hospital
Hyderabad, India
Virinchi Hospital
Hyderabad, India
Yashoda Hospital
Hyderabad, India
Choithram hospital
Indore, India
Dodeja Hospital
Jabalpur, India
Apex Hospital
Jaipur, India
Manipal hospital
Jaipur, India
Shubh Hospital
Jaipur, India
shrimann superspeciality hospital ICU-1
Jalandhar, India
Shrimann Superspeciality Hospital
Jalandhar, India
Kripa Critical Care and Trauma Centre
Jalgaon, India
Smvd Narayana Superspeciality Hospital
Jammu, India
Tata Main Hospital
Jamshedpur, India
All India Institute of Medical Sciences, jodhpur
Jodhpur, India
Ved Hospital
Kalyān, India
Abha superspeciality hospital
Kanpur, India
Regency hospital ltd tower 1
Kanpur, India
Shree krishna hospital ICU-1
Karamsad, India
Shree Krishna Hospital
Karamsad, India
Sankalpa hospital
Khammam, India
Amrita institute of Medical Sciences
Kochi, India
MOSC Medical College
Kochi, India
AMRI Hospital Mukundapur
Kolkata, India
AMRI Hospital, DHAKURIA
Kolkata, India
Apollo Gleneagles Hospital
Kolkata, India
Bellevue Clinic
Kolkata, India
Fortis Hospital Anandapur
Kolkata, India
Institute of Neurosciences Kolkata
Kolkata, India
Medica Superspecialty Hospital
Kolkata, India
Peerless Hospitex Hospital and Research Center Limited
Kolkata, India
Tata Medical Center
Kolkata, India
Travancore medical college,medicity
Kollam, India
Govt.Medical college
Kottayam, India
King George's Medical University
Lucknow, India
Christian Medical College
Ludhiana, India
Apollo speciality hospital
Madurai, India
Kasturba medical college, Manipal
Manipal, India
Nayati medicity hospital
Mathura, India
Manglam Hosp
Meerut, India
Metro Hospital and heart Institute
Meerut, India
Cheema Medical Complex
Mohali, India
Fortis Hospital
Mohali, India
MAX Superspecialty Hospital
Mohali, India
Asian Cancer Institute
Mumbai, India
Bhatia Hospital
Mumbai, India
Dr L H HIRANANDANI HOSPITAL
Mumbai, India
Fortis hiranandani hospital
Mumbai, India
Fortis Hospital Mulund
Mumbai, India
Fortis hospitals
Mumbai, India
Global Hospital,Parel
Mumbai, India
Global Hospital
Mumbai, India
Holy Family Hospital
Mumbai, India
Nanavati Hospital Icu-1
Mumbai, India
Nanavati hospital ICU-2
Mumbai, India
Nanavati Hospital Icu-3
Mumbai, India
Nanavati Hospital
Mumbai, India
Nanavati hosptial
Mumbai, India
Pd Hinduja National Hospital and Mrc
Mumbai, India
s.l.Rahej hospital- a fortis associate
Mumbai, India
Sir H N Reliance Foundation Hospital
Mumbai, India
Suasth Health Care
Mumbai, India
Tata Memorial Hospital (FICU)
Mumbai, India
Tata Memorial Hospital (SICU)
Mumbai, India
Wockhardt Hopsital South Mumbai
Mumbai, India
Cauvery Heart and multispeciality hospital
Mysore, India
Jss Hospital
Mysore, India
Gopalagowda Shanthaveri Memorial Hospital
Mysuru, India
Aditya Hospital
Nagpur, India
Dew medicare and Trinity Hospital
Nagpur, India
Dr V E Tambe Critical Care
Nagpur, India
Meditrina Institute Of Medical Scineces
Nagpur, India
Orange City Hospital And Research Institute
Nagpur, India
Rahate Surgical Hospital and Iccu
Nagpur, India
Shree Hospital and Critical Care Centre
Nagpur, India
Apollo Hospitals
Nashik, India
National Burns Centre
Navi Mumbai, India
Narayana Medical College Icu-1
Nellore, India
Narayana Medical College
Nellore, India
Simhapuri Hospital
Nellore, India
Batra Hospital & Medical Research Center
New Delhi, India
Batra Hospital
New Delhi, India
BLK hospital
New Delhi, India
Blk Superspeciality Hospital
New Delhi, India
Fortis Escorts Heart Institute
New Delhi, India
Fortis Hospital, Shalimar Bagh
New Delhi, India
GB Pant Institute of Post Graduate Medical Education & Research
New Delhi, India
Indraprastha Apollo Hospitals ICU-1
New Delhi, India
Indraprastha apollo hospitals
New Delhi, India
Max Super Specialty Hospital Patparganj
New Delhi, India
Northern railway central hospital
New Delhi, India
Sri balaji action medical institute ICU-1
New Delhi, India
Sri Balaji Action Medical Institute
New Delhi, India
Venkateshwar Hospital
New Delhi, India
Fortis Hospital
Noida, India
Promhex Multispeciality Hospital
Noida, India
Ojas hospital
Panchkula, India
All India Institute of Medical Sciences Patna
Patna, India
Indira Gandhi Institute of Medical Sciences
Patna, India
Prabhat Kumar
Patna, India
Bharati Vidyapeeth Deemed university and Medical College Hospital
Pune, India
Columbia Asia hospital
Pune, India
Jupiter Hospital
Pune, India
Niramaya Hoapital
Pune, India
Ruby Hall Clinic Icu-1
Pune, India
Ruby Hall Clinic ICU-2
Pune, India
Vishwaraj Hospital & Research Centre
Pune, India
Vishwaraj Hospital& Research Center
Pune, India
Om Hospital
Raipur, India
Pt. J. N. M. Medical College
Raipur, India
Ramskrishna care hospital
Raipur, India
Shree Narayana Hospital
Raipur, India
Genesis Multispeciality Hospital
Rajkot, India
Shree Giriraj Multispeciality hospital
Rajkot, India
Shree Giriraj Multispecialty Hospital
Rajkot, India
Sterling Hospital, Rajkot (A Division of Sterling Addlife India Private Limited)
Rajkot, India
Synergy superspeciality hospital
Rajkot, India
Bhagwan Mahavir Medica Superspecialty Hospital
Ranchi, India
Sagarshree Hospital
Sāgar, India
Abdul Waheed Mir
Srinagar, India
Sheri Kashmir Institute of Medical Sciences
Srinagar, India
Kiran Hospital
Surat, India
Shree Sardar Smarak Hospital
Surat, India
Trichy Srm Medical College Hospital & Research Centre
Tiruchirappalli, India
Believers Church Medical College and Hospital
Tiruvalla, India
Kerala Institute of Medical sciences
Trivandrum, India
Siddaganga hospital and research centre
Tūmulūru, India
Sterling Hospitals
Vadodara, India
Homi Bhaba Cancer Hospital & Pandit Madan Mohan Malviya Cancer Centre,Tata Memorial Centre,Varanasi
Varanasi, India
S S Hospital BHU VARANASI
Varanasi, India
Christian Medical College
Vellore, India
Nagarjuna hospital
Vijayawada, India
St Ann Hospital
Visakhapatnam, India
Samraksha super speciality
Warangal, India
Arnam Hospital
Wardha, India
Related Publications (17)
Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2013 Oct 31;369(18):1726-34. doi: 10.1056/NEJMra1208943. No abstract available.
PMID: 24171518BACKGROUNDDellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM; Surviving Sepsis Campaign Management Guidelines Committee. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004 Mar;32(3):858-73. doi: 10.1097/01.ccm.0000117317.18092.e4.
PMID: 15090974BACKGROUNDDellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004 Apr;30(4):536-55. doi: 10.1007/s00134-004-2210-z. Epub 2004 Mar 3.
PMID: 14997291BACKGROUNDDellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008 Jan;36(1):296-327. doi: 10.1097/01.CCM.0000298158.12101.41.
PMID: 18158437BACKGROUNDDellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008 Jan;34(1):17-60. doi: 10.1007/s00134-007-0934-2. Epub 2007 Dec 4.
PMID: 18058085BACKGROUNDDellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.
PMID: 23361625BACKGROUNDDellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
PMID: 23353941BACKGROUNDLevy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC; Surviving Sepsis Campaign. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med. 2010 Feb;38(2):367-74. doi: 10.1097/CCM.0b013e3181cb0cdc.
PMID: 20035219BACKGROUNDLevy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, Dellinger RP. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med. 2015 Jan;43(1):3-12. doi: 10.1097/CCM.0000000000000723.
PMID: 25275252BACKGROUNDLevy MM, Pronovost PJ, Dellinger RP, Townsend S, Resar RK, Clemmer TP, Ramsay G. Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med. 2004 Nov;32(11 Suppl):S595-7. doi: 10.1097/01.ccm.0000147016.53607.c4. No abstract available.
PMID: 15542969BACKGROUNDDamiani E, Donati A, Serafini G, Rinaldi L, Adrario E, Pelaia P, Busani S, Girardis M. Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational studies. PLoS One. 2015 May 6;10(5):e0125827. doi: 10.1371/journal.pone.0125827. eCollection 2015.
PMID: 25946168BACKGROUNDRhodes A, Phillips G, Beale R, Cecconi M, Chiche JD, De Backer D, Divatia J, Du B, Evans L, Ferrer R, Girardis M, Koulenti D, Machado F, Simpson SQ, Tan CC, Wittebole X, Levy M. The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Med. 2015 Sep;41(9):1620-8. doi: 10.1007/s00134-015-3906-y. Epub 2015 Jun 25.
PMID: 26109396BACKGROUNDRhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med. 2017 Mar;45(3):486-552. doi: 10.1097/CCM.0000000000002255.
PMID: 28098591BACKGROUNDRhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18.
PMID: 28101605BACKGROUNDSeymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, Lemeshow S, Osborn T, Terry KM, Levy MM. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med. 2017 Jun 8;376(23):2235-2244. doi: 10.1056/NEJMoa1703058. Epub 2017 May 21.
PMID: 28528569BACKGROUNDLiu VX, Morehouse JW, Marelich GP, Soule J, Russell T, Skeath M, Adams C, Escobar GJ, Whippy A. Multicenter Implementation of a Treatment Bundle for Patients with Sepsis and Intermediate Lactate Values. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1264-70. doi: 10.1164/rccm.201507-1489OC.
PMID: 26695114BACKGROUNDLevy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 update. Intensive Care Med. 2018 Jun;44(6):925-928. doi: 10.1007/s00134-018-5085-0. Epub 2018 Apr 19. No abstract available.
PMID: 29675566BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sheila N Myatra, MD
Tata Memorial Hospital, Parel, Mumbai-12
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 19, 2019
First Posted
October 29, 2019
Study Start
October 22, 2019
Primary Completion
January 31, 2023
Study Completion
January 31, 2023
Last Updated
October 24, 2022
Record last verified: 2022-10
Data Sharing
- IPD Sharing
- Will not share
There is not a plan to make individual participant data available