Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients

NCT03475667 | Completed

• 1 other identifier: 2018-27-DM-EXP
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Inaccurate monitoring of mean arterial pressure (MAP) could lead to improper treatment in the form of excessive fluid infusion or unnecessary vasopressor therapy; therefore, accurate hemodynamic monitoring is crucial in treatment of septic shock. In critically ill septic patients treated with vasoactive drugs, many studies reported that radial arterial pressure monitoring significantly underestimates central arterial pressure. Insertion of a femoral line allowed a substantial reduction of the infusion rate of vasoactive drugs in these patients. These findings might imply that femoral placement of arterial lines is the gold standard for invasive arterial blood pressure monitoring in shock patient. Our study aimed to determine the difference between radial (peripheral) and femoral (central) arterial pressures measured simultaneously in a group of critically ill patients receiving high dose noradrenaline therapy (≥ 0.1 mcg/kg/min).

Conditions

Septic Shock

Keywords

Septic Shock; hemodynamic monitoring; blood pressure determination

Outcome Measures

Primary Outcomes (1)

• To compare radial and femoral arterial invasive blood pressure measurements in patients receiving high dose of noradrenaline (≥ 0.1 mcg/kg/min).

  Comparison of radial and femoral artery site invasive blood pressure measurement in septic patients on high dose of noradrenaline

  Within 5 minutes of placement of femoral artery catheter

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Critically ill patients having septic shock on high dose of noradrenaline (≥0.1 mcg/kg/min) for at least 30 minutes.

You may qualify if:

• All ICU patients who are ≥18 years with septic shock on high dose of noradrenaline (≥0.1 mcg/kg/min) for at least 30 minutes

You may not qualify if:

• Age \<18 years
• Pregnancy
• Patient who cannot be made supine as per clinical condition
• Patients having abdominal compartment syndrome
• Known peripheral vascular disease

Sponsors & Collaborators

• Sanjay Gandhi Postgraduate Institute of Medical Sciences: lead

Study Sites (1)

Department of Critical Care Medicine, SGPGIMS

Lucknow, Uttar Pradesh, 226014, India

Location

Related Publications (1)

• Bhaskar B, Gurjar M, Mishra P, Azim A, Poddar B, Baronia AK. Arterial site selection for measurement of mean arterial pressure in septic shock patients on high-dose norepinephrine. Front Med (Lausanne). 2022 Dec 23;9:1019752. doi: 10.3389/fmed.2022.1019752. eCollection 2022.

  PMID: 36619630 RESULT

MeSH Terms

Conditions

Shock, Septic

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Officials

• Mohan Gurjar, MD, PDCC

  Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 18, 2018
• First Posted: March 23, 2018
• Study Start: April 11, 2018
• Primary Completion: January 10, 2020
• Study Completion: January 10, 2020
• Last Updated: February 14, 2023

Record last verified: 2023-02

Locations

IN (1)