NCT04139005

Brief Summary

There is no single definition of well-being, but consensus exists that positive functioning beyond the absence of detrimental mental health symptoms is central. Building on related "eudaimonic" frameworks of psychological flourishing that identify qualities like environmental mastery, positive relations with others, and personal growth, this study targets brain-based skills that underlie the active cultivation of such qualities (e.g., regulating attention, empathic care, mental flexibility), and thus offers straightforward hypotheses about mechanisms of change. The Healthy Minds Program (HMP) is designed to promote and protect psychological well-being through sustainable skills training. The program is grounded in constituents of psychological well-being identified in empirical literature. HMP provides core content, with instruction administered through a curriculum of high-quality guided practices. HMP is based on research on eudaimonic well-being (e.g., environmental mastery, purpose) and brain-based skills that underlie these qualities (e.g., regulation of attention, mental flexibility). HMP practices address 4 constituents of well-being: awareness, connection, insight, and purpose. This pilot focuses on awareness, connection, and insight.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
383

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2019

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 15, 2019

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

October 23, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 25, 2019

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 8, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 8, 2021

Completed
Last Updated

January 26, 2021

Status Verified

October 1, 2020

Enrollment Period

1.2 years

First QC Date

October 23, 2019

Last Update Submit

January 22, 2021

Conditions

Outcome Measures

Primary Outcomes (9)

  • Change in Depression symptoms as assessed by PROMIS Depression score

    Self-reported experience of depression symptoms over the past 7 days. Eight items are scored on a scale of 1-5 (1 = never experience, 5 = always experience).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in Anxiety symptoms as assessed by PROMIS Anxiety score

    Self-reported experience of anxiety symptoms over the past 7 days. Eight items are scored on a scale of 1-5 (1 = never experience, 5 = always experience).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in Perceived Stress Scale

    Self-reported stressful experiences over the past month. Fourteen items are scored on a scale of 0-4 (0 = never experience, 4 = very often experience).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in the Social Connectedness Scale score

    Self-reported feelings related to social connection. Twenty items are scored on a scale of 1-6 (1 = strongly disagree, 6 = strongly agree).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in Dispositional empathy as assessed by Interpersonal Reactivity Scale

    Self-reported thoughts and feelings related to empathy. Twenty-eight items are scored on a scale of A-E (A = does not describe me well, E = describes me very well).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in Compassion as assessed by Compassionate Love Scale

    Self-reported feelings of compassion for close others and humanity. Twenty-one items are scored on a scale of 1-7 (1 = not true at all of me, 7 = very true of me).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in Self-Reflection and Insight Scale score

    Self-reported thoughts of introspection and self-understanding. Twenty items are scored on a scale of 1-6 (1 = strongly disagree, 6 = strongly agree).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in repetitive negative thinking as assessed by Perseverative Thinking Questionnaire score

    Self-reported experiences with negative thoughts. Fifteen items are scored on a scale of 0-4 (0 = never, 4 = almost always).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

  • Change in the Defusion as assessed by Drexel Defusion Scale

    Self-reported distancing from internal experiences during difficult hypothetical situations. Ten items are scored on a scale of 0-5 (0 = not at all, 5 = very much).

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

Secondary Outcomes (3)

  • App Usage as assessed by number of logins

    up to 9 month follow-up

  • App Usage as assessed by minutes of practice each day

    up to 9 month follow-up

  • Change in the Mindfulness (Five Factor Mindfulness Questionnaire)

    Baseline, 4-6 weeks, 10-12 weeks, 3 month follow-up, 6 month follow-up, 9 month follow-up

Study Arms (3)

Awareness-Connection

EXPERIMENTAL
Behavioral: AwarenessBehavioral: Connection

Awareness-Insight

EXPERIMENTAL
Behavioral: AwarenessBehavioral: Insight

Wait list

NO INTERVENTION

Interventions

AwarenessBEHAVIORAL

The program foundation targets attention and awareness skills that are integral to many conceptions of mindfulness.

Also known as: Healthy Minds Program
Awareness-ConnectionAwareness-Insight
ConnectionBEHAVIORAL

The Connection module targets skills underlying social connection, which refers to the sense of having close and positively experienced relationships with others in the social world.

Also known as: Healthy Minds Program
Awareness-Connection
InsightBEHAVIORAL

The Insight module targets skills underlying dynamic self-inquiry and experiential self-knowledge.

Also known as: Healthy Minds Program
Awareness-Insight

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between the age of 18-65

You may not qualify if:

  • Individuals under 18 or over 65
  • Significant meditation experience (as defined below):
  • Meditation retreat experience (meditation retreat or yoga/body practice retreat with significant meditation component).
  • Regular meditation practice weekly for over 1 year OR daily practice within the previous 6 months.
  • Previous practice under the instruction of a meditation teacher, other than in the context of an introductory course.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Healthy Minds

Madison, Wisconsin, 53703, United States

Location

Related Publications (1)

  • Goldberg SB, Imhoff-Smith T, Bolt DM, Wilson-Mendenhall CD, Dahl CJ, Davidson RJ, Rosenkranz MA. Testing the Efficacy of a Multicomponent, Self-Guided, Smartphone-Based Meditation App: Three-Armed Randomized Controlled Trial. JMIR Ment Health. 2020 Nov 27;7(11):e23825. doi: 10.2196/23825.

MeSH Terms

Interventions

Immunization Programs

Intervention Hierarchy (Ancestors)

Preventive Health ServicesHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Melissa Rosenkranz, PhD

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR
  • Simon Goldberg, PhD

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 23, 2019

First Posted

October 25, 2019

Study Start

October 15, 2019

Primary Completion

January 8, 2021

Study Completion

January 8, 2021

Last Updated

January 26, 2021

Record last verified: 2020-10

Data Sharing

IPD Sharing
Will share

Any collected data may be made anonymous and transmitted through shared folders, via email, by usb, or other avenues and made available upon request or shared publicly in an open science format. All identifiers (i.e., names, contact information, date of birth, visit dates) will be stripped to assure confidentiality of this data.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
Data may be shared following analysis and publication or upon request.

Locations