NCT04122820

Brief Summary

To evaluate, in primary care, the sensitivity of Heterophory-Vertical-Labile (HV-Labile) in ambulatory screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD). in children aged 8 to 12 years.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,800

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2019

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 5, 2019

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 10, 2019

Completed
6 days until next milestone

Study Start

First participant enrolled

October 16, 2019

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2021

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2022

Completed
Last Updated

October 18, 2019

Status Verified

October 1, 2019

Enrollment Period

2 years

First QC Date

October 5, 2019

Last Update Submit

October 17, 2019

Conditions

Keywords

Specific Learning DisorderDevelopmental Coordination DisorderSpecific Developmental Disorders of Speech and LanguageDyslexia, DevelopmentalDyspraxia

Outcome Measures

Primary Outcomes (1)

  • Sensitivity of the HV-Labile to SLD or DCD

    Estimated and provided with its 95% confidence interval.

    through study completion, an average of 3 year

Secondary Outcomes (6)

  • Specificity of the HV-Labile to SLD or DCD

    through study completion, an average of 3 year

  • Positive and negative likelihood ratios

    through study completion, an average of 3 year

  • Prevalence of children with HV-Labile

    through study completion, an average of 3 year

  • Correlation coefficient between the symptomatic proprioceptive questionnaire and the presence of HV-Labile

    through study completion, an average of 3 year

  • Positive predictive values

    through study completion, an average of 3 year

  • +1 more secondary outcomes

Other Outcomes (1)

  • Calculation of results based on a Cut Off at -1.5 standard deviation, or -2 standard deviation, to determine the presence of a SLD or a DCD

    through study completion, an average of 3 year

Study Arms (2)

Presence of HV-Labile

OTHER

Presence of vertical heterophoria labile with proprioceptive Maddox

Diagnostic Test: Diagnostic of specific learning disabilities or of Developmental Coordination Disorder

Absence of HV-Labile

OTHER

Presence of stable vertical heterophoria or stable orthophoria with proprioceptive Maddox

Diagnostic Test: Diagnostic of specific learning disabilities or of Developmental Coordination Disorder

Interventions

Speech therapy assessment, or occupational therapy. In case of pathological disorder, search for a sensory disorder, and therapeutic management. If the pathological disorder persists for more than six months, elimination of a secondary etiology.

Absence of HV-LabilePresence of HV-Labile

Eligibility Criteria

Age8 Years - 12 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • The population studied is composed of children:
  • from 8 to 12 years old
  • seen for any reason for consultation in general practice
  • Schooled in an ordinary environment since the Preparatory Course in France
  • Francophone parents
  • One of whose parents has signed the consent
  • Consent of the child
  • Social Insured

You may not qualify if:

  • The background and living conditions that may promote secondary learning disabilities, for example:
  • Child with a known intellectual disability (Wisc)
  • Child in IME (Institut Médico Educatif)
  • Child followed in SESSAD (Specialised education service at home)
  • Child not knowing how to answer the questions asked
  • Child with a known etiology causing learning disabilities (epilepsy, autism spectrum disorder, hearing impairment, visual impairment (deafness, blindness, low vision))
  • Child on treatment (antiepileptic, neuroleptic, antidepressant, anxiolytic)
  • Child under the care of a psychiatrist,
  • Child followed by the CMP (Centre médico-psychologique)
  • Child living in an institution,
  • Adopted child
  • A child whose mother has experienced known depression during the child's early childhood (0-18 months) because it causes attachment disorders, which can impact the child's development, including learning
  • Child of a family that has lived through more than two family recompositions
  • Child known to be a victim of abuse.
  • Out of school child.
  • +5 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Office-based general practioner

Strasbourg, Alsace, 67000, France

RECRUITING

Related Publications (1)

  • Quercia P, Quercia M, Feiss LJ, Allaert F. The distinctive vertical heterophoria of dyslexics. Clin Ophthalmol. 2015 Sep 25;9:1785-97. doi: 10.2147/OPTH.S88497. eCollection 2015.

Related Links

MeSH Terms

Conditions

LanguageSpecific Learning DisorderDyslexiaMotor Skills DisordersApraxias

Condition Hierarchy (Ancestors)

CommunicationBehaviorLearning DisabilitiesCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurodevelopmental DisordersMental DisordersLanguage DisordersPsychomotor Disorders

Study Officials

  • Luc Virlet

    SCalab CNRS 9193, Lille University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
An adjudication committee to determine the presence or absence of a specific learning disability will be set up, regardless of the presence of a central reference instability.
Purpose
SCREENING
Intervention Model
PARALLEL
Model Details: Comparison of the presence of a specific learning disability, or a Developmental Coordination Disorder, in the case of the presence or absence of referential instability of central origin.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

October 5, 2019

First Posted

October 10, 2019

Study Start

October 16, 2019

Primary Completion

October 30, 2021

Study Completion

October 30, 2022

Last Updated

October 18, 2019

Record last verified: 2019-10

Data Sharing

IPD Sharing
Will not share

IPD will not be shared with other researchers.

Locations