Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD)

NCT02393729 | Completed

• 2 other identifiers: 10 155 02N°RCB : 2010-A00909-30
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

All the studies underlined the high frequency of co-morbid associations in specific learning disorders. Understanding the reasons for these associations could enable us to determine the cerebral bases that underlie each disorder. Their frequent association suggests the etiological bases are partly common, it seems logical to turn to explanatory models of various common specific disorders. The model recently proposed by Nicholson \& Fawcett (2007) suggests a specific disorder of procedural learning. But the brain networks involved in this learning could be achieved separately. We intend therefore to study the neural networks involved in learning procedural and compare networks recruited among children with specific learning disorder alone or in combination (co-morbidity). The children included in the study have either a Developmental Dyslexia or a Developmental Coordination Disorder, or both. The procedure includes a neuropsychological evaluation and a brain MRI study with a morphological and a functional part. During fMRI the child realizes a automated motor task contrasting with a task involving learning procedural.

Conditions

Developmental Dyslexia; Developmental Coordination Disorder

Outcome Measures

Primary Outcomes (2)

• difference in the level of brain activity

  The difference in the level of brain activity obtained by contrasting the result of the automated task and that task with learning in the same patient-adjusted performance.

  1 day

• The level of brain activity obtained by fMRI

  The level of brain activity obtained by fMRI will be estimated by the blood flow in milliliters per minute using a standardized procedure and validated specific MRI used and managed entirely by dedicated software (SPM8 - Welcome Department of Cognitive Neurology, London, UK). The performance adjustment is made in the analysis of the estimated difference in blood flow using a mixed model. Regions of interest are the primary motor cortex, the supplementary motor area, the pre motor cortex, the striatum and the cerebellum. These regions will be studied in both hemispheres.

  1 day

Secondary Outcomes (1)

• The performance of subjects

  1 day

Study Arms (4)

children with DCD

OTHER

Children with Developmental Coordination Disorder (DCD) will have neuropsychological assessment and MRI study

Behavioral: Neuropsychological assessment; Other: MRI Study

children with DD

OTHER

Children with Developmental Dyslexia (DD) will have neuropsychological assessment and MRI study

Behavioral: Neuropsychological assessment; Other: MRI Study

children with DCD + DD

OTHER

Neuropsychological assessment and MRI study

Behavioral: Neuropsychological assessment; Other: MRI Study

control children

OTHER

Neuropsychological assessment and MRI study

Behavioral: Neuropsychological assessment; Other: MRI Study

Interventions

Neuropsychological assessment BEHAVIORAL

The neuropsychological assessment will include an assessment of: * Intellectual ability * Laterality * Reading Skills * Motor skills * Oral Language * Attention * Child's behaviour

children with DCD; children with DCD + DD; children with DD; control children

MRI Study OTHER

It will include a first session of about an hour outside MRI for familiarization with the environment of the MRI. The MRI will then be made after a break of 15 minutes * Morphological time: this time include the initial acquisition of a sequence of anatomical 3D T1-weighted high-resolution contiguous axial slices and the imaging of diffusion tensor. * Functional time: The experimental paradigm is a paradigm as a block with alternating phase of motor and rest conditions. The two motor tasks are: a Learning motor sequence or motor sequence task and Automated motor sequence or AT (automated task).

Also known as: structural and functional MRI

children with DCD; children with DCD + DD; children with DD; control children

Eligibility Criteria

• Age: 8 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• These children presenting either a specific disorder in learning to read (developmental dyslexia or DD) type phonological or mixed as defined by World Health Organisation or a Developmental Coordination Disorder (DCD) as defined by Diagnostic and Statistical Manual IV criteria or the association of both disorders (DCD + DD).
• Or in the control group:
• Children and their parents must have given their free and informed consent signed. The representative of the child shall be affiliated to a social security scheme.
• The children included in the study will be all right handed.

You may not qualify if:

• Mental retardation as defined by DSM IV criteria by an estimated IQ from the Wechsler scales less than 70.
• The presence of a dyslexia-type surface defined by a specific disorder in learning to read without difficulty for metaphonological tests and/or an exclusive impairment of the addressing reading route (reading irregular words).
• Children regularly practicing a musical instrument conferring a high manual dexterity such as piano or guitar.
• The presence of a cons-indication for a MRI.

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

Hôpital des Enfants

Toulouse, 31073, France

Location

Related Publications (2)

• Biotteau M, Peran P, Vayssiere N, Tallet J, Albaret JM, Chaix Y. Neural changes associated to procedural learning and automatization process in Developmental Coordination Disorder and/or Developmental Dyslexia. Eur J Paediatr Neurol. 2017 Mar;21(2):286-299. doi: 10.1016/j.ejpn.2016.07.025. Epub 2016 Aug 12.

  PMID: 27546352 RESULT

• Biotteau M, Albaret JM, Lelong S, Chaix Y. Neuropsychological status of French children with developmental dyslexia and/or developmental coordination disorder: Are both necessarily worse than one? Child Neuropsychol. 2017 May;23(4):422-441. doi: 10.1080/09297049.2015.1127339. Epub 2016 Jan 4.

  PMID: 26729293 RESULT

MeSH Terms

Conditions

Dyslexia; Motor Skills Disorders

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Specific Learning Disorder; Learning Disabilities; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Yves Chaix, MD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 13, 2015
• First Posted: March 19, 2015
• Study Start: January 1, 2011
• Primary Completion: September 1, 2013
• Study Completion: September 1, 2013
• Last Updated: May 12, 2017

Record last verified: 2017-05

Locations

FR (1)