NCT04121689|Completed
Time Course of Postprandial Protein Metabolism
Time-dependent Regulation of Postprandial Muscle Protein Synthesis After Milk Protein Ingestion in Young Men
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Time-dependent Regulation of Postprandial Muscle Protein Synthesis After Milk Protein Ingestion in Young Men
Sponsor study identifier
interventional
7
1 country
1
Study Start
October 1, 2014
Actual (reported)Primary Completion
November 1, 2014
Actual (reported)Study Completion
August 26, 2019
Actual (reported)The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults. Our aim was assess the time course of anabolic signaling events and stimulation of muscle protein synthesis rates (MPS) after ingestion of a food source that represents a more typical meal-induced pattern of aminoacidemia, namely milk protein concentrate, in healthy young males.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 26, 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 1, 2014
Actual (reported)November 1, 2014
Actual (reported)August 26, 2019
Actual (reported)September 3, 2019
Actual (reported)October 10, 2019
Actual (reported)Fractional synthesis rates of myofibrillar protein
Myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hours, and every 1-2 hours during the 5 hours after protein ingestion. This will allow us assess the timecourse of muscle protein synthesis after eating.
8 hours
Phosphorylation of muscle anabolic signaling
8 hours
Exogenous rate of phenylalanine appearance
5 hours
Seven young men (age: 22±1 y) will undergo repeated blood and biopsy sampling during primed continuous L-\[ring-2H5\]phenylalanine and L-\[1-13C\]leucine tracer infusions, and ingested 38 g of L-\[1-13C\]phenylalanine- and L-\[1-13C\]leucine-labeled milk protein concentrate
The macronutrient composition and energy of the milk protein beverage provided to participants is 38 g protein (3.46 g leucine), 4.17 g carbohydrate, and 1.4 g fat. The milk protein met all chemical and bacteriologic specifications for human consumption. The L-\[1-13C\]phenylalanine and L-\[1-13C\]leucine enrichments in the milk protein concentrate averaged 38.3 and 10.8 mole percent excess (MPE), respectively.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Freer Hall
Urbana, Illinois, 61801, United States
7 participants (actual enrollment reported by the registry).
First Submitted
September 3, 2019
First Posted
October 10, 2019
Study Start
October 1, 2014
Actual (reported)Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women
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Primary Completion
November 1, 2014
Actual (reported)Study Completion
August 26, 2019
Actual (reported)Last Updated
October 10, 2019
Record last verified: 2019-08
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Source: ClinicalTrials.gov.
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