Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry

NCT04110912 | Withdrawn

• 1 other identifier: Rescu Epistry
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 3

Brief Summary

Rescu Epistry includes data points pertaining to prehospital and in-hospital clinical treatments and responses to therapy, survival to discharge and functional outcome data for all cases.

Conditions

Cardiac Arrest; Sepsis; Trauma; Stroke

Keywords

Cardiac arrest, Trauma, Acute stroke, and Sepsis

Outcome Measures

Primary Outcomes (1)

• Data Registry

  To collect comprehensive, standardized, multicentre prehospital data to guide future EMS and Fire as well as in-hospital care (e.g. Emergency Department (ED), Trauma Room, Critical Care Units (CrCU), ward care and rehabilitation) for cardiac arrest, trauma, stroke, and sepsis patients.

  1 year (annual)

Secondary Outcomes (4)

• Effectiveness and Translation

  1 year (annual)

• Evaluation

  1 year (annual)

• International Collaboration in both Efficacy and Effectiveness

  1 year (annual)

• Examine epidemiologic and outcomes

  1 year (annual)

Study Arms (4)

Cardiac arrest

Ischaemic heart disease is the leading cause of death worldwide. However, this is a registry and no interventions are taking place

Other: This is a registry and no interventions are taking place.

Trauma

Worldwide, trauma is the number one cause of death and disability in people younger than 40 and confirmed for Canada as well for those under the age of 45. However, this is a registry and no interventions are taking place

Other: This is a registry and no interventions are taking place.

Sepsis

Sepsis is a clinical syndrome that results from dysregulation of the inflammatory response to severe infection. However, this is a registry and no interventions are taking place

Other: This is a registry and no interventions are taking place.

Stroke

Stroke is the second leading cause of death worldwide, and the leading cause of chronic disability. However, this is a registry and no interventions are taking place

Other: This is a registry and no interventions are taking place.

Interventions

This is a registry and no interventions are taking place. OTHER

Cardiac arrest; Sepsis; Stroke; Trauma

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All persons within the catchment area of any EMS agency participating, including infants, children and adult patients requiring activation of the emergency 9-1-1 system that meet the defined criteria for cardiac arrest, traumatic injury, stroke or sepsis.

You may qualify if:

• Cardiac Arrest Eligibility
• Individuals of all ages who experience cardiac arrest outside the hospital, with evaluation by organized EMS personnel and:
• Attempts at external defibrillation (by lay responders or emergency personnel), or chest compressions by organized EMS personnel (treated cohort)
• Were pulseless but did not receive attempts to defibrillate or CPR by EMS personnel (untreated cohort - obviously dead by legislative definition)
• Traumatic Injury Eligibility
• Individuals of all ages who experience a traumatic injury outside the hospital, with evaluation by organized EMS personnel and:
• Systolic blood pressure ≤ 90 mmHg or
• Glasgow Coma Scale score ≤12 or
• Respiratory rate \<10 or \>29 breaths per minute or
• Field intubation/advanced airway procedure
• Stroke Eligibility
• individuals of all ages who experience stroke outside the hospital, with evaluation by organized EMS personnel and new onset of signs and symptoms suggestive of an acute stroke
• Unilateral arm/leg weakness or drift or
• Slurred speech or inappropriate words or mute or
• Unilateral facial droop

Sponsors & Collaborators

• Unity Health Toronto: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• Heart and Stroke Foundation of Canada: collaborator

Study Sites (3)

Hamilton Health Sciences

Hamilton, Ontario, L8V 1C3, Canada

Location

Sunnybrook Health Sciences Center

Toronto, Ontario, M4N 3M5, Canada

Location

St Michael's Hospital

Toronto, Ontario, M5V 1W8, Canada

Location

Related Publications (3)

• Lin S, Morrison LJ, Brooks SC. Development of a data dictionary for the Strategies for Post Arrest Resuscitation Care (SPARC) network for post cardiac arrest research. Resuscitation. 2011 Apr;82(4):419-22. doi: 10.1016/j.resuscitation.2010.12.006. Epub 2011 Jan 26.

  PMID: 21276647 RESULT

• Lin S, Turgulov A, Taher A, Buick JE, Byers A, Drennan IR, Hu S, J Morrison L. Automated Data Abstraction of Cardiopulmonary Resuscitation Process Measures for Complete Episodes of Cardiac Arrest Resuscitation. Acad Emerg Med. 2016 Oct;23(10):1178-1181. doi: 10.1111/acem.13032. Epub 2016 Sep 27.

  PMID: 27320008 RESULT

• Sun CL, Demirtas D, Brooks SC, Morrison LJ, Chan TC. Overcoming Spatial and Temporal Barriers to Public Access Defibrillators Via Optimization. J Am Coll Cardiol. 2016 Aug 23;68(8):836-45. doi: 10.1016/j.jacc.2016.03.609.

  PMID: 27539176 RESULT

MeSH Terms

Conditions

Heart Arrest; Sepsis; Wounds and Injuries; Stroke

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 2, 2017
• First Posted: October 1, 2019
• Study Start: January 1, 2015
• Primary Completion (Estimated): December 1, 2040
• Study Completion (Estimated): December 1, 2040
• Last Updated: October 1, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will share

Locations

CA (3)