NCT04081155

Brief Summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2019

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2019

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

September 3, 2019

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 9, 2019

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 28, 2020

Completed
4 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2020

Completed
Last Updated

July 14, 2020

Status Verified

January 1, 2019

Enrollment Period

1.4 years

First QC Date

September 3, 2019

Last Update Submit

July 12, 2020

Conditions

Mechanical Ventilation ComplicationRespiratory FailureHypoxia

Keywords

EITpulmonary perfusionventilation

Outcome Measures

Primary Outcomes (2)

  • lung regional ventilation distribution

    lung regional ventilation distribution measured by EIT

    Hour 1

  • lung regional perfusion distribution

    lung regional perfusion distribution measured by EIT

    Hour 1

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

adult patients within 7 days, who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study

You may qualify if:

  • have been placed central venous catheter based on patient's condition
  • Under mechanically ventilation
  • Under sedation and control ventilation mode
  • Year\>18

You may not qualify if:

  • Pneumothorax
  • pregnancy
  • Severe chest wall wound
  • Severe hypernatremia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Peking Union Medical College Hospital, Chinese Academy of Medical Science

Beijing, Beijing Municipality, China

Location

Related Publications (1)

  • He H, Chi Y, Long Y, Yuan S, Frerichs I, Moller K, Fu F, Zhao Z. Influence of overdistension/recruitment induced by high positive end-expiratory pressure on ventilation-perfusion matching assessed by electrical impedance tomography with saline bolus. Crit Care. 2020 Sep 29;24(1):586. doi: 10.1186/s13054-020-03301-x.

    PMID: 32993811DERIVED

MeSH Terms

Conditions

Respiratory InsufficiencyHypoxiaRespiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration DisordersRespiratory Tract DiseasesSigns and Symptoms, RespiratorySigns and SymptomsPathological Conditions, Signs and SymptomsPathologic Processes

Study Officials

  • Yun Long

    Peking Union Medical College Hospital

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
the director of the intensive care medicine

Study Record Dates

First Submitted

September 3, 2019

First Posted

September 9, 2019

Study Start

January 1, 2019

Primary Completion

May 28, 2020

Study Completion

June 1, 2020

Last Updated

July 14, 2020

Record last verified: 2019-01

Locations

CN(1)