PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT

NCT06594601 | Recruiting

• 2 other identifiers: PEEP by 3D-EIT for ARDSPUMCH
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well as the extent of lung collapse and overdistension as detected by 3D-EIT.

Conditions

ARDS; Respiratory Failure

Keywords

ARDS; EIT; 3D-EIT

Outcome Measures

Primary Outcomes (1)

• OD/CL and optimal PEEP monitored by EIT

  Monitoring the lung collapse and overdistension region by EIT at different PEEP levels. Measure the optimal PEEP level based on collapse and overdistension rate.

  5-10min

Secondary Outcomes (4)

• ventilation distribution monitored by EIT

  5-10min

• GI monitored by EIT

  5-10min

• CoV monitored by EIT

  5-10min

• V/Q monitored by EIT

  5-10min

Study Arms (2)

lung recruitment potential assessed by 3D EIT in ARDS

Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung recruitment potential assessment by 3D EIT( as the follwoing mentioned )

Procedure: lung recruitment potential assessed by 3D EIT

PEEP titration by 3D EIT for ARDS

Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung PEEP tirtation by 3D EIT( as the follwoing mentioned )

Procedure: PEEP titration by 3D eit

Interventions

lung recruitment potential assessed by 3D EIT PROCEDURE

Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The lung recruitment potential assessed by 3D EIT was as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. PEEP was switched to a zero end-expiratory pressure (ZEEP) for 10 min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) \> 90%. 3. PEEP was stepwise increase from 0 to 15 cmH2O PEEP in steps of 5cm H2O every 3min.And 3D EIT was used to assess lung recruitment potential.

lung recruitment potential assessed by 3D EIT in ARDS

PEEP titration by 3D eit PROCEDURE

Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The PEEP titriatino by 3D EIT fwas as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. RM: PEEP was switched to a 21cmH2O for 2min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) ≥90%. 3. PEEP was stepwise decrease from 21 to 0 cmH2O PEEP in steps of 3cm H2O every 2min. 4. 3D EIT was used to monitor regional ventilation distribution during PEEP titration.

PEEP titration by 3D EIT for ARDS

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with ARDS on mechanical ventilation.

You may qualify if:

• patients on mechanical ventilation.
• Diagnosis of ARDS was based on the Berlin definition
• lung recruitment potential assessment and PEEP titration was proper for the ARDS patients determined by the attending doctor

You may not qualify if:

• Under 18 years of age.
• Pregnant women;
• Ribcage malformation
• Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
• Hemodynamic instability, unable to tolerate high PEEP;
• High-risk individuals with pneumothorax, mediastinal emphysema, etc.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,

Beijing, Beijing Municipality, 100730, China

RECRUITING

MeSH Terms

Conditions

Respiratory Insufficiency

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases

Study Officials

• Huaiwu He, PhD

  Department of Critical Care Medicine, Peking Union Medical College, Peking Union Medical College Hospital

  PRINCIPAL INVESTIGATOR

• Yun Long, PhD

  Department of Critical Care Medicine, Peking Union Medical College, Peking Union Medical College Hospital

  STUDY DIRECTOR

Central Study Contacts

Huaiwu He

CONTACT

15201518815; tjmuhhw@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 2, 2024
• First Posted: September 19, 2024
• Study Start: January 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

CN (1)