Application of Indicator Based-electrical Impedance Tomography Method Assess Lung Regional Perfusion in ICU Patients

NCT04081142 | Completed

• 1 other identifier: EIT-lung Perfusion in ICU
• Study Type: observational
• Target: 119
• Locations: 1 country
• Sites: 1

Brief Summary

This study is an observational study. Investigate the relationship of oxgenation and lung regional ventilation and perfusion assessed by the indicator based-EIT method in the critically ill patients in ICU

Conditions

Respiratory Failure; Hypoxemia; ARDS, Human

Keywords

EIT, pulmonary perfusion

Outcome Measures

Primary Outcomes (2)

• Lung regional perfusion

  Lung regional perfusion monitored by EIT with saline

  Hour 1

• oxygenation

  oxygenation(SpO2) measured by bedside monitor

  Hour 1

Study Arms (2)

acute respiratory failure group

acute respiratory failure (ARF) group: arterial oxygen partial pressure to fractional inspired oxygen ratio, PaO2/FiO2\<300 mmHg and/or peripheral oxygen saturation SaO2\<94% under air condition and/or severe dyspnea with respiratory rate \>30bpm.

control group

postoperative ICU patients without ARF were included

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

adult patients within 7days, who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters for clinical requirment were eligible for the study.

You may qualify if:

• Time of admission ICU \< 7days
• Age (\> 18 years old)
• Have been placed central venous catheter based on clinical requirement

You may not qualify if:

• Chest skin injured and cannot be monitored by EIT.
• Severe Hypernatremia
• Pregnancy

Sponsors & Collaborators

• Yun Long: lead

Study Sites (1)

Peking Union Medical College Hospital, Chinese Academy of Medical Science

Beijing, Beijing Municipality, 100730, China

Location

Related Publications (2)

• Wang Q, Su L, Jiang J, Wang N, He H, Long Y. Incorporating electrical impedance tomography to transpulmonary pressure-guided PEEP in severe ARDS with pneumothorax and multiple cavitations: a case report. Front Med (Lausanne). 2023 Aug 28;10:1240321. doi: 10.3389/fmed.2023.1240321. eCollection 2023.

  PMID: 37700773 DERIVED

• He H, Chi Y, Long Y, Yuan S, Zhang R, Yang Y, Frerichs I, Moller K, Fu F, Zhao Z. Three broad classifications of acute respiratory failure etiologies based on regional ventilation and perfusion by electrical impedance tomography: a hypothesis-generating study. Ann Intensive Care. 2021 Aug 28;11(1):134. doi: 10.1186/s13613-021-00921-6.

  PMID: 34453622 DERIVED

MeSH Terms

Conditions

Respiratory Insufficiency; Hypoxia; Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Lung Diseases

Study Officials

• Yun Long

  Peking Union Medical College Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: the director of the intensive care medicine

Study Record Dates

• First Submitted: September 3, 2019
• First Posted: September 9, 2019
• Study Start: May 1, 2018
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: December 21, 2020

Record last verified: 2020-12

Locations

CN (1)