Environmental Temperature and Human White Adipose Tissue

NCT04037371 | Completed

• 1 other identifier: 1. PET/CT & Tenv
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is characterized by excessive white adipose tissue (WAT) that increases risk for disease. About 700 million adults are obese worldwide, designating the need of reducing excessive WAT in humans and subsequently the risk for disease. For this reason, previous research focused on the thermogenic capacity of white adipocytes in response to cold exposure. The investigators aimed to identify whether human WAT thermogenic activation could alter energy homeostasis and subsequently total body weight. The human WAT thermogenic capacity was assessed via Positron Emission Tomography/Computed Tomography (PET/CT) examination.

Conditions

Obesity; Obesity, Abdominal; Obese

Keywords

Cold exposure; white fat cells; thermoregulation; winter

Outcome Measures

Primary Outcomes (1)

• Correlation between white adipose tissue activity and environmental temperature. Mean differences in white adipose tissue activity between those participants who were assessed in winter and those who were assessed in summer.

  White adipose tissue activity was assessed using a PET/CT examination to calculate the standardized uptake value (SUV) in dorsolumbar region near vertebrae L3 and abdominal region. Daily environmental temperature was obtained in degrees Celsius from the Weather Underground (www.wunderground.com) webpage for the period between January 2017 and February 2019

  An overall of 10 hours of an assessment period that including two hours of cold exposure, 30 minutes of resting energy expenditure and 40 minutes of PET/CT assessments

Interventions

Cold exposure OTHER

Participants were tested for white fat thermogenic activity against their environmental temperature exposure

Eligibility Criteria

• Age: Up to 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

20 healthy adult men \[age: 36.30±5.33 (years); Body Mass Index: 28.46±5.49 (kg/m2)\]

You may qualify if:

• healthy adult men
• no chronic disease
• not being under medication treatment
• non-smoking individuals
• non-regular exercisers individuals

You may not qualify if:

• non-adult men
• women
• chronic disease
• being under medication treatment
• smokers
• regular exercisers

Sponsors & Collaborators

• Petros Dinas: lead

Study Sites (1)

Petros Dinas

Trikala, Thessaly, 42100, Greece

Location

MeSH Terms

Conditions

Obesity; Obesity, Abdominal

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Andreas Flouris, PhD

  FAME Laboratory, Department of Exercise Science, University of Thessaly

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Senior Researcher in human physiology

Study Record Dates

• First Submitted: July 22, 2019
• First Posted: July 30, 2019
• Study Start: April 2, 2017
• Primary Completion: January 16, 2018
• Study Completion: March 30, 2018
• Last Updated: July 30, 2019

Record last verified: 2019-07

Locations

GR (1)