The Effect of Cold Exposure on Energy Expenditure

NCT05107570 | Completed

• 1 other identifier: WEU
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (\~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.

Conditions

Cold Exposure

Keywords

Cold exposure; Energy expenditure

Outcome Measures

Primary Outcomes (1)

• Cold-induced thermogenesis

  Energy expenditure with indirect calorimetry

  30 min before and during the cold exposure (maximum 1 hour)

Secondary Outcomes (4)

• Skin temperature

  30 min before and during the cold exposure (maximum 1 hour)

• Core temperature

  30 min before and during the cold exposure (maximum 1 hour)

• Shivering activity

  30 min before and during the cold exposure (maximum 1 hour)

• Substrate oxidation

  30 min before and during the cold exposure (maximum 1 hour)

Study Arms (2)

Cold exposure applied to Western European individuals

OTHER

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched Siberian individuals.

Other: Cold exposure

Cold exposure applied to Siberian individuals

OTHER

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched European individuals.

Other: Cold exposure

Interventions

Cold exposure OTHER

Cold air exposure (\~ 9°C, maximum 1 hour duration)

Cold exposure applied to Siberian individuals; Cold exposure applied to Western European individuals

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Signed informed consent
• Western European origin or of Siberian origin
• BMI between 18.5 and 35 kg/m2
• Generally healthy (determined by dependent physician)

You may not qualify if:

• Smoking
• Active, uncontrolled cardiovascular disease or cancer
• Raynaud's disease
• Participation in another biomedical study within 1 month before the first study
• Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
• Medication use known to hamper subject's safety during study procedures
• Abuse of alcohol or drugs

Sponsors & Collaborators

• Maastricht University: lead

Study Sites (1)

Maastricht University

Maastricht, 6229 ER, Netherlands

Location

Study Officials

• W. van Marken Lichtenbelt, PhD

  Maastricht University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 21, 2021
• First Posted: November 4, 2021
• Study Start: May 17, 2021
• Primary Completion: May 2, 2022
• Study Completion: May 2, 2022
• Last Updated: July 28, 2022

Record last verified: 2022-07

Locations

NL (1)