Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in the Preservation of the Tooth Socket
Teh Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in Teh Preservation of Teh Tooth Socket
1 other identifier
interventional
20
1 country
1
Brief Summary
Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in teh research project, which TEMPhas more TEMPthan 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for teh periodontal problem, caries or Fractures were selected.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Feb 2018
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 23, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 10, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 25, 2019
CompletedFirst Submitted
Initial submission to the registry
May 13, 2019
CompletedFirst Posted
Study publicly available on registry
June 10, 2019
CompletedJune 11, 2019
June 1, 2019
1 year
May 13, 2019
June 8, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
New bone formation (bone area as percent)
Combination Lovastatin produced increased vital bone more percentage compared to the nanocrystal bone graft alone group. The new bone formation and alveolar ridge preservation with bone graft after extraction of pre-molar teeth could result in the maintenance of sufficient bone volume to place an implant in an ideal restorative position without the need for auxiliary implant site development procedures.
3 month
Study Arms (2)
Alendronate 20 mg with bone graft
ACTIVE COMPARATORafter tooth extraction, put teh Alendronate 20mg with bone graft within teh tooth socket
bone graft alone
ACTIVE COMPARATORafter tooth extraction, put the bone graft within the tooth socket
Interventions
The Alendronate 20 mg combined with nanocrystalline hydroxyapatite as a synthetic bone substitute for socket preservation after tooth extraction
Postextraction Sockets Preserved With Nanocrystal hydroxyapatite as a synthetic bone substitute alone as a bone graft
Eligibility Criteria
You may qualify if:
- at least 18 years old
- tooth fracture, root caries
- Patients are volunteered for placement of teh implant
You may not qualify if:
- systemic diseases
- Pregnancy and breastfeeding
- malignancy, radiation therapy,
- history of periodontal surgery during teh six months ago.
- medicine(phosphonates, antibiotic,...)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Amirhossein Farahmand
Tehran, 19, Iran
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- assistant prof
Study Record Dates
First Submitted
May 13, 2019
First Posted
June 10, 2019
Study Start
February 23, 2018
Primary Completion
March 10, 2019
Study Completion
April 25, 2019
Last Updated
June 11, 2019
Record last verified: 2019-06
Data Sharing
- IPD Sharing
- Will not share