Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft

NCT03007069 | Unknown

• 1 other identifier: CairoMPM-ABG
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards.

Conditions

Bone Resorption

Outcome Measures

Primary Outcomes (1)

• Patient Satisfaction regarding esthetic results , outcome will be measure using questionnaire.

  5 months

Secondary Outcomes (1)

• Stability of dental implants , this will be measured using Ostell device in ISQ units.

  5 months.

Study Arms (2)

Autogenous bone graft (Gold Standard).

EXPERIMENTAL

Patients with defective maxillary alveolar ridges requiring implant insertion will have Autogenous bone graft (Gold standard) and collagen membrane to be used for bone augmentation around exposed threads of inserted dental implants.

Other: Autogenous bone graft (gold standard).

MPM Augmentation.

ACTIVE COMPARATOR

Mineralized plasmatic matrix (MPM) to be used without collagen membrane to augment the defect in the maxillary bone and cover the exposed threads of the dental implants.

Other: Mineralized plasmatic matrix (MPM).

Interventions

Mineralized plasmatic matrix (MPM). OTHER

By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM, for 10 minutes , Which will result if sticky bone graft consistency after mixing.

Also known as: Sticky bone graft.

MPM Augmentation.

Autogenous bone graft (gold standard). OTHER

Exposed implant threads are to be covered with autogenous bone and collagen membrane.

Also known as: Autobone.

Autogenous bone graft (Gold Standard).

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Medically free patients.
• Evaluated bone height on CBCT to be (0-4 mm buccal bone dehiscence) and width (not less than 4.5 mm)
• Patients with Anterior maxillary defective partially edentulous ridge.
• Age between 18 and 40 years.
• Both sexes.
• Patients physically able to tolerate surgical and restorative procedures.
• Patients with an opposing tooth to the pre-implant site.
• Good oral hygiene.
• Highly motivated patients.

You may not qualify if:

• Patients allergic to local anesthetic agent.
• Pregnant or lactating females.
• Presence of any pathosis in the pre-implant site.
• Presence of any mucosal disease.
• Presence of parafunctional habits.
• History of oral radiotherapy.
• History of prolonged steroids use.
• Psychological disorders.

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Bone Resorption

Interventions

1-methyl-1-piperidinomethane sulfonate

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dentist at menistry of health

Study Record Dates

• First Submitted: December 25, 2016
• First Posted: January 2, 2017
• Study Start: January 1, 2017
• Primary Completion: September 1, 2017
• Study Completion: December 1, 2017
• Last Updated: January 2, 2017

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will not share