NCT03978520

Brief Summary

The main objective of this study was to evaluate the safety and efficacy of elsubrutinib, upadacitinib (UPA), and ABBV-599 (elsubrutinib/upadacitinib) High Dose and Low Dose combinations vs placebo for the treatment of signs and symptoms of Systemic Lupus Erythematosus (SLE) in participants with moderately to severely active SLE and to define doses for further development.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
341

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jul 2019

Typical duration for phase_2

Geographic Reach
21 countries

160 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 3, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 7, 2019

Completed
2 months until next milestone

Study Start

First participant enrolled

July 25, 2019

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 19, 2022

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 14, 2022

Completed
1 year until next milestone

Results Posted

Study results publicly available

July 21, 2023

Completed
Last Updated

July 21, 2023

Status Verified

June 1, 2023

Enrollment Period

2.5 years

First QC Date

June 3, 2019

Results QC Date

June 27, 2023

Last Update Submit

June 27, 2023

Conditions

Keywords

Systemic Lupus Erythematosus (SLE)ABBV-105UpadacitinibABBV-599Elsubrutinib

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants Achieving SLE Responder Index (SRI)-4 and Steroid Dose ≤ 10 mg Prednisone Equivalent Once a Day (QD) at Week 24

    SLE Responder Index (SRI)-4 is defined as follows with all criteria compared to Baseline: * ≥ 4-point reduction in Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score * No worsening of the overall condition (\< 0.3 point increase in Physician's Global Assessment \[PhGA\]) * No new British Isles Lupus Assessment Group (BILAG) A or more than 1 new BILAG B disease activity scores (i.e., no organ system changes from baseline B/C/D/E to A and no more than 1 organ system changes from baseline C/D/E to B). A letter score is assigned to each organ system with following indications: A = severe, B = moderate, C = mild, D = inactive with prior history, and E = inactive with no history.

    Baseline, Week 24

Secondary Outcomes (5)

  • Percentage of Participants Achieving SLE Responder Index (SRI)-4 at Week 24

    Baseline, Week 24

  • Percentage of Participants Achieving British Isles Lupus Assessment Group (BILAG) Based Combined Lupus Assessment (BICLA) Response at Week 24

    Baseline, Week 24

  • Percentage of Participants Achieving Lupus Low Disease Activity State (LLDAS) at Week 24

    Baseline, Week 24

  • Change From Baseline in Daily Prednisone Dose at Week 24

    From Baseline to Week 24

  • Number of Flares Per Patient-year by Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) SLEDAI Flare Index Through Week 24

    From Baseline to Week 24

Study Arms (5)

Elsubrutinib placebo/upadacitinib placebo

PLACEBO COMPARATOR

Placebo capsule for elsubrutinib once a day by mouth for up to 48 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for up to 48 weeks

Drug: Placebo for elsubrutinibDrug: Placebo for upadacitinib

ABBV-599 High Dose (Elsubrutinib 60 mg/upadacitinib 30 mg)

EXPERIMENTAL

60 mg elsubrutinib capsule once a day by mouth for up to 48 weeks; 30 mg upadacitinib film-coated tablet once a day by mouth for up to 48 weeks

Drug: ElsubrutinibDrug: Upadacitinib

Elsubrutinib placebo/upadacitinib 30 mg

EXPERIMENTAL

Placebo capsule for elsubrutinib once a day by mouth for up to 48 weeks; 30 mg upadacitinib film-coated tablet once a day by mouth for up to 48 weeks

Drug: Placebo for elsubrutinibDrug: Upadacitinib

ABBV-599 Low Dose (Elsubrutinib 60 mg/upadacitinib 15 mg)

EXPERIMENTAL

60 mg elsubrutinib capsule once a day by mouth for up to 24 weeks; 15 mg upadacitinib film-coated tablet once a day by mouth for up to 24 weeks

Drug: ElsubrutinibDrug: Upadacitinib

Elsubrutinib 60 mg/upadacitinib placebo

EXPERIMENTAL

60 mg elsubrutinib capsule once a day by mouth for up to 24 weeks; placebo film-coated tablet for upadacitinib once a day by mouth for up to 24 weeks

Drug: ElsubrutinibDrug: Placebo for upadacitinib

Interventions

Capsule; Oral

Also known as: ABBV-105
ABBV-599 High Dose (Elsubrutinib 60 mg/upadacitinib 30 mg)ABBV-599 Low Dose (Elsubrutinib 60 mg/upadacitinib 15 mg)Elsubrutinib 60 mg/upadacitinib placebo

Capsule; Oral

Elsubrutinib placebo/upadacitinib 30 mgElsubrutinib placebo/upadacitinib placebo

Film-coated tablet; Oral

Also known as: RINVOQ
ABBV-599 High Dose (Elsubrutinib 60 mg/upadacitinib 30 mg)ABBV-599 Low Dose (Elsubrutinib 60 mg/upadacitinib 15 mg)Elsubrutinib placebo/upadacitinib 30 mg

Film-coated tablet; Oral

Elsubrutinib 60 mg/upadacitinib placeboElsubrutinib placebo/upadacitinib placebo

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participant has clinical diagnosis of Systemic Lupus Erythematosus (SLE) at least 24 weeks prior to Screening, meeting at least 4 of the 11 revised Criteria for Classification of SLE according to the 1997 Update of the 1982 American College of Rheumatology (ACR) OR meeting at least 4 of the 2012 SLICC classification criteria, including at least 1 clinical criterion and 1 immunologic criterion.
  • At Screening, must have at least one of the following:
  • antinuclear antibody (ANA)+ (titer ≥ 1:80)
  • anti-dsDNA+
  • anti-Smith+
  • SLEDAI-2K (SLE Disease Activity Index) ≥ 6 despite background therapy as reported and independently adjudicated (clinical score ≥ 4, excluding lupus headache and/or organic brain syndrome) at Screening:
  • If 4 points of the required entry points are for arthritis, there must also be a minimum of 3 tender and 3 swollen joints.
  • If participant has rash and Principal Investigator (PI) considers it to be attributable to SLE, participant must consent to skin photograph collection for adjudication.
  • Score must be re-confirmed at the Baseline visit.
  • Physician's Global Assessment (PhGA) ≥ 1 during screening period.
  • Must be on background treatment, stable for 30 days prior to Baseline and throughout the study with antimalarial(s), prednisone (or prednisone equivalent) (≤ 20 mg), azathioprine (≤ 150 mg), mycophenolate (\<2 g), leflunomide (≤ 20 mg), cyclosporine, tacrolimus, and/or methotrexate (MTX) (≤ 20 mg).
  • No combinations of the above with immunomodulators other than prednisone (or equivalents) and antimalarials.

You may not qualify if:

  • \- Participant using intravenous (IV) or intramuscular (IM) corticosteroids greater than or equal to a 40 mg prednisone-equivalent bolus within 30 days of planned randomization.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (160)

Arizona Arthritis & Rheumatology Research, PLLC /ID# 214522

Mesa, Arizona, 85210-6871, United States

Location

AZ Arthritis and Rheumotology Research, PLLC /ID# 211329

Phoenix, Arizona, 85032-9306, United States

Location

AZ Arthritis and Rheumotology Research, PLLC /ID# 214267

Phoenix, Arizona, 85032-9306, United States

Location

Arthritis and Rheumatism Associates /ID# 211411

Jonesboro, Arkansas, 72401-6251, United States

Location

Wallace Rheumatic Studies Center, LLC /ID# 211600

Beverly Hills, California, 90211, United States

Location

Arthritis & Osteo Medical Ctr /ID# 228235

La Palma, California, 90623-1728, United States

Location

Valerius Medical Group & Research Center /ID# 211599

Los Alamitos, California, 90720-5402, United States

Location

East Bay Rheumatology Medical /ID# 211638

San Leandro, California, 94578, United States

Location

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 213402

Torrance, California, 90502, United States

Location

Medvin Clinical Research /ID# 211996

Tujunga, California, 91042-2706, United States

Location

Inland Rheum Clin Trials Inc. /ID# 213617

Upland, California, 91786, United States

Location

University of Colorado Hospital /ID# 211314

Aurora, Colorado, 80045, United States

Location

Yale University /ID# 212824

New Haven, Connecticut, 06510, United States

Location

Medstar Health Research Institute /ID# 213335

Washington D.C., District of Columbia, 20010, United States

Location

Arthritis & Rheumatic Disease Specialties /ID# 214052

Aventura, Florida, 33180, United States

Location

LeJenue Research Associates /ID# 212327

Miami, Florida, 33126, United States

Location

Ctr Arthritis & Rheumatic Dise /ID# 212326

Miami, Florida, 33173, United States

Location

Millennium Research /ID# 219099

Ormond Beach, Florida, 32174, United States

Location

IRIS Research and Development, LLC /ID# 213053

Plantation, Florida, 33324, United States

Location

West Broward Rheumatology Associates /ID# 211881

Tamarac, Florida, 33321, United States

Location

BayCare Medical Group, Inc. /ID# 218818

Tampa, Florida, 33614-7101, United States

Location

Affinity Clinical Research /ID# 211496

Oak Brook, Illinois, 60523-1245, United States

Location

Deerbrook Medical Associates /ID# 212251

Vernon Hills, Illinois, 60061, United States

Location

Qualmedica Research, LLC /ID# 214765

Evansville, Indiana, 47714-0805, United States

Location

University of Iowa Hospitals and Clinics /ID# 215246

Iowa City, Iowa, 52242, United States

Location

The Center for Rheumatology and Bone Research /ID# 211610

Wheaton, Maryland, 20902, United States

Location

Beth Israel Deaconess Medical Center /ID# 212321

Boston, Massachusetts, 02215-5400, United States

Location

Henry Ford Health System /ID# 211676

Detroit, Michigan, 48202, United States

Location

June DO, PC /ID# 211674

Lansing, Michigan, 48910, United States

Location

West County Rheumatology /ID# 225051

St Louis, Missouri, 63131-1703, United States

Location

NYU Langone Ambulatory Care Brooklyn Heights /ID# 211548

Brooklyn, New York, 11201, United States

Location

NYU Langone Orthopedic Center /ID# 213620

New York, New York, 10016-2772, United States

Location

Ohio State University - Wexner Medical Center /ID# 211636

Columbus, Ohio, 43210-1229, United States

Location

STAT Research, Inc. /ID# 211404

Vandalia, Ohio, 45377-9464, United States

Location

Premier Rheumatology of Oklahoma /ID# 213850

Tulsa, Oklahoma, 74136-2117, United States

Location

Allegheny Health Network Research Institute /ID# 211607

Pittsburgh, Pennsylvania, 15224, United States

Location

Univ TN Health Sciences Ctr /ID# 212177

Memphis, Tennessee, 38103, United States

Location

Dr. Ramesh Gupta /ID# 213381

Memphis, Tennessee, 38119, United States

Location

Tekton Research, Inc. /ID# 211521

Austin, Texas, 78745, United States

Location

Tekton Research, Inc. /ID# 214182

Austin, Texas, 78745, United States

Location

Trinity Universal Research Associates - Carrollton /ID# 211527

Carrollton, Texas, 75007, United States

Location

Accurate Clinical Management /ID# 213571

Houston, Texas, 77084, United States

Location

West Texas Clinical Research /ID# 211529

Lubbock, Texas, 79424, United States

Location

SW Rheumatology Res. LLC /ID# 211520

Mesquite, Texas, 75150, United States

Location

Carilion Clinic /ID# 213500

Roanoke, Virginia, 24016, United States

Location

Virginia Mason Medical Center /ID# 211457

Seattle, Washington, 98101, United States

Location

Rheumatology and Pulmonary Clinic /ID# 211398

Beckley, West Virginia, 25801, United States

Location

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 221685

Ciudad Autonoma Buenos Aires, Buenos Aires, 1426, Argentina

Location

Hospital Interzonal General de Agudos General Jose de San Martin /ID# 211679

La Plata, Buenos Aires, 1900, Argentina

Location

CER Instituto Medico /ID# 222757

Quilmes, Buenos Aires, 1878, Argentina

Location

Aprillus Asistencia e Investigacion /ID# 211630

Ciudad Autonoma de Buenos Aire, Ciuadad Autonoma de Buenos Aires, 1046, Argentina

Location

Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 211634

Rosario, Santa Fe Province, 2000, Argentina

Location

Instituto CAICI S.R.L /ID# 211633

Rosario, Santa Fe Province, 2000, Argentina

Location

Centro de Investigaciones Medicas Tucuman /ID# 212714

San Miguel de Tucumán, Tucumán Province, 4000, Argentina

Location

Investigaciones Clinicas Tucuman /ID# 211942

San Miguel de Tucumán, Tucumán Province, 4000, Argentina

Location

Hospital Cordoba /ID# 212200

Córdoba, 5000, Argentina

Location

Emeritus Research Sydney /ID# 222983

Botany, New South Wales, 2019, Australia

Location

Royal North Shore Hospital /ID# 222982

St Leonards, New South Wales, 2065, Australia

Location

Royal Brisbane and Women's Hospital /ID# 212667

Herston, Queensland, 4029, Australia

Location

Rheumatology Research Unit Sunshine Coast /ID# 211902

Maroochydore, Queensland, 4558, Australia

Location

Griffith University /ID# 223543

Southport, Queensland, 4222, Australia

Location

The Queen Elizabeth Hospital /ID# 211901

Woodville South, South Australia, 5011, Australia

Location

Emeritus Research /ID# 211903

Camberwell, Victoria, 3124, Australia

Location

Monash Medical Centre /ID# 212313

Clayton, Victoria, 3168, Australia

Location

St Vincent's Hospital Melbourne /ID# 212311

Fitzroy Melbourne, Victoria, 3065, Australia

Location

UMHAT Kaspela EOOD /ID# 223141

Plovdiv, 4001, Bulgaria

Location

UMHAT Sveti Ivan Rilski /ID# 223139

Sofia, 1431, Bulgaria

Location

UMHAT Sveti Ivan Rilski /ID# 223140

Sofia, 1431, Bulgaria

Location

Hamilton Health Sciences - McMaster University Medical Centre /ID# 212662

Hamilton, Ontario, L8S 4K1, Canada

Location

St. Josephs Health Care Centre /ID# 212331

London, Ontario, N6A 4V2, Canada

Location

Toronto Western Hospital /ID# 213336

Toronto, Ontario, M5T 2S8, Canada

Location

Diex Recherche Sherbrooke Inc. /ID# 217734

Sherbrooke, Quebec, J1L 0H8, Canada

Location

Anhui Provincial Hospital /ID# 211812

Hefei, Anhui, 230001, China

Location

Peking Union Medical College Hospital /ID# 211614

Beijing, Beijing Municipality, 100730, China

Location

Guangdong Provincial People's Hospital /ID# 211811

Guangzhou, Guangdong, 510080, China

Location

Xiangya Hospital Central South University /ID# 212919

Changsha, Hunan, 410008, China

Location

Jiangsu Province Hospital /ID# 211818

Nanjing, Jiangsu, 210029, China

Location

Huashan Hospital, Fudan University /ID# 213976

Shanghai, Shanghai Municipality, 200040, China

Location

Shanghai Changhai Hospital /ID# 211819

Shanghai, Shanghai Municipality, 200433, China

Location

People's Hospital of Xinjiang /ID# 211821

Ürümqi, 830001, China

Location

Centro Integral de Reumatologia del Caribe Circaribe SAS /ID# 211894

Barranquilla, Atlántico, 80002, Colombia

Location

Centro de Investigacion en Reumatologia y Especialidades Medicas- CIREEM SAS /ID# 211895

Bogota, Cundinamarca, 110221, Colombia

Location

Preventive Care Sas /Id# 211896

Chía, Cundinamarca, 250001, Colombia

Location

Healthy Medical Center SAS /ID# 211899

Zipaquirá, Cundinamarca, 250252, Colombia

Location

Clinica Universitaria Bolivari /ID# 211897

Medellín, 050034, Colombia

Location

CHRU Lille - Hopital Claude Huriez /ID# 211829

Lille, Hauts-de-France, 59037, France

Location

CHU Bordeaux - Hopital Pellegrin /ID# 211832

Bordeaux, 33000, France

Location

AP-HP - Hôpital Bicêtre /ID# 211968

Le Kremlin-Bicêtre, 94270, France

Location

Hopital Pitie Salpetriere /ID# 211831

Paris, 75013, France

Location

CHU Strasbourg - Hopital Civil /ID# 211981

Strasbourg, 67091, France

Location

Universitaetsklinikum Duesseldorf /ID# 212408

Düsseldorf, North Rhine-Westphalia, 40225, Germany

Location

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 212674

Kiel, Schleswig-Holstein, 24105, Germany

Location

Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 211988

Berlin, 10117, Germany

Location

Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 212770

Dresden, 01307, Germany

Location

Debreceni Egyetem Klinikai Kozpont /ID# 212042

Debrecen, Hajdú-Bihar, 4032, Hungary

Location

Vital Medical Center Orvosi es Fogaszati Kozpont /ID# 212796

Veszprém, Veszprém megye, 8200, Hungary

Location

Orszagos Reumatologiai es Fizioterapias Intezet /ID# 211827

Budapest, 1023, Hungary

Location

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 216971

Gyula, 5700, Hungary

Location

Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant Anna /ID# 211861

Cona, Ferrara, 44124, Italy

Location

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 212195

Rome, Lazio, 00161, Italy

Location

ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 215063

Milan, 20122, Italy

Location

Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 211858

Udine, 33100, Italy

Location

Chukyo Hospital /ID# 222625

Nagoya, Aichi-ken, 457-8510, Japan

Location

NHO Nagoya Medical Center /ID# 213974

Nagoya, Aichi-ken, 460-0001, Japan

Location

Hamanomachi Hospital /ID# 213696

Fukuoka, Fukuoka, 810-8539, Japan

Location

Hospital of the University of Occupational and Environmental Health, Japan /ID# 217548

Kitakyushu-shi, Fukuoka, 807-8556, Japan

Location

Fukushima Medical University Hospital /ID# 213913

Fukushima, Fukushima, 960-1295, Japan

Location

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 213694

Hiroshima, Hiroshima, 730-8619, Japan

Location

National Hospital Organization Asahikawa Medical Center /ID# 213846

Asahikawa-shi, Hokkaido, 070-8644, Japan

Location

Tomakomai City Hospital /ID# 214234

Tomakomai-shi, Hokkaido, 053-0034, Japan

Location

Kita-harima Medical Center /ID# 215474

Ono-shi, Hyōgo, 675-1327, Japan

Location

EIRAKU Internal Medicine Clinic /ID# 215419

Kagoshima, Kagoshima-ken, 890-0063, Japan

Location

Yokohama Rosai Hospital /ID# 213690

Yokohama, Kanagawa, 222-0036, Japan

Location

Kumamoto Shinto General Hospital /ID# 215347

Kumamoto, Kumamoto, 862-8655, Japan

Location

Tohoku University Hospital /ID# 213693

Sendai, Miyagi, 9808574, Japan

Location

Shinshu University Hospital /ID# 213853

Matsumoto-shi, Nagano, 390-8621, Japan

Location

Nagano Red Cross Hospital /ID# 214572

Nagano, Nagano, 380-8582, Japan

Location

Saitama Medical Center /ID# 213687

Kawagoe-shi, Saitama, 350-8550, Japan

Location

Keio University Hospital /ID# 216347

Shinjuku-ku, Tokyo, 160-8582, Japan

Location

Morales Vargas Centro de Investigacion S.C. /ID# 212946

León, Guanajuato, 37000, Mexico

Location

Centro Integral en Reumatologia S.A de C.V /ID# 211876

Guadalajara, Jalisco, 44160, Mexico

Location

Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 212532

Guadalajara, Jalisco, 44690, Mexico

Location

RM Pharma Specialists S.A de C.V. /ID# 211879

Mexico City, Mexico City, 03100, Mexico

Location

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 211875

Mexico City, Mexico City, 11850, Mexico

Location

Centro de Alta Especialidad en Reumatología e Investigación del Potosí, SC /ID# 212737

San Luis Potosí City, San Luis Potosí, 78213, Mexico

Location

Medical Care & Research SA de CV /ID# 212682

Mérida, Yucatán, 97070, Mexico

Location

Vrije Universiteit Medisch Centrum /ID# 214424

Amsterdam, 1081 HV, Netherlands

Location

Leids Universitair Medisch Centrum /ID# 214413

Leiden, 2333 ZA, Netherlands

Location

Universitair Medisch Centrum Utrecht /ID# 214415

Utrecht, 3584 CX, Netherlands

Location

Middlemore Clinical Trials /ID# 213504

Papatoetoe, Auckland, 2025, New Zealand

Location

North Shore Hospital /ID# 213506

Takapuna, Auckland, 0622, New Zealand

Location

Waikato Hospital /ID# 213505

Hamilton, Waikato Region, 3240, New Zealand

Location

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 212483

Poznan, Greater Poland Voivodeship, 61-545, Poland

Location

Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 212146

Krakow, Lesser Poland Voivodeship, 31-011, Poland

Location

WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 212482

Wroclaw, Lower Silesian Voivodeship, 51-685, Poland

Location

Centrum Medyczne Pratia Warszawa /ID# 218176

Warsaw, Masovian Voivodeship, 01-868, Poland

Location

GCM Medical Group PSC /ID# 211251

San Juan, 00917-3104, Puerto Rico

Location

Mindful Medical Research /ID# 213384

San Juan, 00918-3756, Puerto Rico

Location

Ajou University Hospital /ID# 211692

Suwon, Gyeonggido, 16499, South Korea

Location

KonKuk University Medical Center /ID# 213410

Seoul, Seoul Teugbyeolsi, 05030, South Korea

Location

Chonnam National University Hospital /ID# 211695

Gwangju, 61469, South Korea

Location

Inha University Hospital /ID# 211691

Incheon, 22332, South Korea

Location

Seoul National University Hospital /ID# 211740

Seoul, 03080, South Korea

Location

HUA - Txagorritxu /ID# 212520

Vitoria-Gasteiz, Alava, 01009, Spain

Location

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 212145

Sabadell, Barcelona, 08208, Spain

Location

Hospital Universitario Basurto /ID# 212722

Bilbao, Vizcaya, 48013, Spain

Location

Hospital Universitario de Galdakao /ID# 212803

Galdakao, Vizcaya, 48960, Spain

Location

Hospital Universitario A Coruna - CHUAC /ID# 211719

A Coruña, 15006, Spain

Location

Hospital Universitario 12 de Octubre /ID# 211757

Madrid, 28041, Spain

Location

Hospital Universitario Virgen de Valme /ID# 212721

Seville, 41014, Spain

Location

Hospital Universitario y Politecnico La Fe /ID# 211720

Valencia, 46026, Spain

Location

China Medical University Hospital /ID# 212179

Taichung, 40447, Taiwan

Location

Taichung Veterans General Hospital /ID# 211957

Taichung, 40705, Taiwan

Location

National Taiwan University Hospital /ID# 211752

Taipei, 100, Taiwan

Location

Taipei Medical University Hospital /ID# 221600

Taipei, 11031, Taiwan

Location

Taipei Veterans General Hosp /ID# 212216

Taipei, 11217, Taiwan

Location

Linkou Chang Gung Memorial Hospital /ID# 211751

Taoyuan, 333, Taiwan

Location

Guys and St Thomas NHS Foundation Trust /ID# 211931

London, London, City of, SE1 9RT, United Kingdom

Location

Cambridge University Hospitals NHS Foundation Trust /ID# 213189

Cambridge, CB2 0QQ, United Kingdom

Location

Manchester University NHS Foundation Trust /ID# 211838

Manchester, M13 9WL, United Kingdom

Location

Related Publications (1)

  • Hannon CW, McCourt C, Lima HC, Chen S, Bennett C. Interventions for cutaneous disease in systemic lupus erythematosus. Cochrane Database Syst Rev. 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2.

Related Links

MeSH Terms

Conditions

Lupus Erythematosus, Systemic

Interventions

upadacitinib

Condition Hierarchy (Ancestors)

Connective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Global Medical Services
Organization
AbbVie

Study Officials

  • ABBVIE INC.

    AbbVie

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 3, 2019

First Posted

June 7, 2019

Study Start

July 25, 2019

Primary Completion

January 19, 2022

Study Completion

July 14, 2022

Last Updated

July 21, 2023

Results First Posted

July 21, 2023

Record last verified: 2023-06

Data Sharing

IPD Sharing
Will share

AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information (e.g., protocols, analyses plans, clinical study reports), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
For details on when studies are available for sharing visit https://vivli.org/ourmember/abbvie/
Access Criteria
Access to this clinical trial data can be requested by any qualified researchers who engage in rigorous independent scientific research, and will be provided following review and approval of a research proposal and statistical analysis plan and execution of a data sharing statement. Data requests can be submitted at any time after approval in the US and/or EU and a primary manuscript is accepted for publication. For more information on the process, or to submit a request, visit the following link https://www.abbvieclinicaltrials.com/hcp/data-sharing/
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