NCT03971552

Brief Summary

The objective was to assess if performing a pre-intervention gadolinium-enhanced extracranial magnetic resonance angiogram (MRA) in addition to intracranial vascular imaging was associated with improved thrombectomy time metrics. Consecutive patients (912) treated by mechanical thrombectomy (MT) at a large comprehensive stroke center between January 2012 and December 2017 who were screened using pre-intervention MRI were included. Patient's characteristics and procedural data were collected. Analyses were performed to compare mechanical thrombectomy speed, efficacy, complications, and clinical outcomes between patients with and without pre-intervention gadolinium-enhanced extracranial MRA.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
912

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2012

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2017

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2018

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

May 26, 2019

Completed
8 days until next milestone

First Posted

Study publicly available on registry

June 3, 2019

Completed
Last Updated

June 3, 2019

Status Verified

May 1, 2019

Enrollment Period

6 years

First QC Date

May 26, 2019

Last Update Submit

May 31, 2019

Conditions

Stroke

Keywords

Mechanical thrombectomyMagnetic resonance angiographyAngiogramAngiographyMagnetic resonance imagingRevascularization

Outcome Measures

Primary Outcomes (1)

  • time from groin puncture to clot contact

    in minute time from onset to recanalization complications \[embolic or hemorrhagic\]

    1 day

Secondary Outcomes (1)

  • modified Rankin Score

    3 months

Interventions

gadolinium-enhanced extracranial magnetic resonance angiogramPROCEDURE

288 of the 912 acute ischemic stroke patients received gadolinium-enhanced extracranial MRA additionally to the standardized stroke MRI imaging protocol.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Acute ischemic stroke (AIS) patients who underwent magnetic resonance imaging (MRI) based screening for acute neurovascular evaluation and who underwent mechanical thrombectomy (MT) at one comprehensive stroke center.

You may qualify if:

  • Acute ischemic stroke

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 26, 2019

First Posted

June 3, 2019

Study Start

January 1, 2012

Primary Completion

December 31, 2017

Study Completion

April 1, 2018

Last Updated

June 3, 2019

Record last verified: 2019-05

Data Sharing

IPD Sharing
Will not share