NCT01917955

Brief Summary

The purpose of this prospective single-center trial is to compare the safety and diagnostic value of contrast medium-enhanced cardiac magnetic resonance imaging and transesophageal echocardiography in patients with acute ischemic stroke.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
103

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2012

Typical duration for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 7, 2012

Completed
1 year until next milestone

First Posted

Study publicly available on registry

August 7, 2013

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2014

Completed
Last Updated

November 8, 2016

Status Verified

November 1, 2016

Enrollment Period

2.8 years

First QC Date

August 7, 2012

Last Update Submit

November 7, 2016

Conditions

Keywords

MRI

Outcome Measures

Primary Outcomes (1)

  • Sensitivity and specificity of contrast medium-enhanced cardiac magnetic resonance imaging to detect echocardiography-proven cardiac sources of embolism in patients with acute ischemic stroke.

    < 1 week after ischemic stroke

Secondary Outcomes (1)

  • Rate of unrecognised myocardial infarction detected by late gadolinium-enhanced cardiac MRI in patients with acute ischemic stroke.

    < 1 week after ischemic stroke

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Overall, 103 patients with acute ischemic stroke detected by brain magnetic resonance imaging will be enrolled.

You may qualify if:

  • Patients with acute ischemic stroke detected by brain magnetic resonance imaging.

You may not qualify if:

  • Known atrial fibrillation or cardiac source of embolism
  • Severe aphasia
  • Acute infection or chronic inflammation
  • Severe arteriosclerosis or stenosis of brain-supplying arteries
  • Contraindications for magnetic resonance imaging or transesophageal echocardiography.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin

Berlin, 12203, Germany

Location

Elisabeth Hospital

Essen, Germany

Location

Related Publications (1)

  • Haeusler KG, Wollboldt C, Bentheim LZ, Herm J, Jager S, Kunze C, Eberle HC, Deluigi CC, Bruder O, Malsch C, Heuschmann PU, Endres M, Audebert HJ, Morguet AJ, Jensen C, Fiebach JB. Feasibility and Diagnostic Value of Cardiovascular Magnetic Resonance Imaging After Acute Ischemic Stroke of Undetermined Origin. Stroke. 2017 May;48(5):1241-1247. doi: 10.1161/STROKEAHA.116.016227. Epub 2017 Apr 14.

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Prof. Matthias Endres, MD

    Center for Stroke Research Berlin

    STUDY CHAIR
  • Karl Georg Haeusler, MD

    Center for Stroke Research Berlin

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

August 7, 2012

First Posted

August 7, 2013

Study Start

January 1, 2012

Primary Completion

November 1, 2014

Study Completion

November 1, 2014

Last Updated

November 8, 2016

Record last verified: 2016-11

Locations