Physiological Benefits of High-intensity Interval Training for Individuals With Parkinson's Disease

NCT03940261 | Completed

• 1 other identifier: 18-08-001
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Aerobic exercise is recommended for individuals with Parkinson's disease (PD) and can improve quality of life, both physically and mentally. The most efficacious program to achieve these exercise benefits is unknown. Recently, high-intensity interval training (HIIT) has been shown to be safe and more effective in many high-risk populations with limited exercise tolerance. Shorter bouts of exercise are likely better tolerated in PD due to difficulty sustaining muscle contractions. The goal of this project is to determine whether HIIT produces superior cardiorespiratory, neuromuscular, biomechanical, and clinical adaptations than conventional continuous moderate intensity training (CMIT) in PD.

Conditions

Parkinson Disease; Exercise Training

Keywords

High intensity interval training

Outcome Measures

Primary Outcomes (1)

• Maximal exercise capacity

  VO2 max

  Change from baseline following 10 weeks of aerobic exercise training

Secondary Outcomes (5)

• Handgrip strength

  Change from baseline following 10 weeks of aerobic exercise training

• Blood Pressure

  Change from baseline following 10 weeks of aerobic exercise training

• Heart Rate

  Change from baseline following 10 weeks of aerobic exercise training

• Mini-Balance Evaluation Systems Test (Mini-BESTest)

  Change from baseline following 10 weeks of aerobic exercise training

• Unified Parkinson's Disease Rating Scale (UPDRS)

  Change from baseline following 10 weeks of aerobic exercise training

Study Arms (2)

High Intensity Interval Training

EXPERIMENTAL

Other: High Intensity Interval Training

Continuous Moderate Intensity Training

ACTIVE COMPARATOR

Other: Continuous Moderate Intensity Training

Interventions

High Intensity Interval Training OTHER

Participants will complete exercise training 3x/week for 10 weeks. Exercise will consist of 10, 1-minute cycling intervals at 90% of peak power output, each separated by 1-min at 10% peak power output.

High Intensity Interval Training

Continuous Moderate Intensity Training OTHER

Participants will complete exercise training 3x/week for 10 weeks. Exercise will consist of 30-50 minutes of cycling at 60% peak power output.

Continuous Moderate Intensity Training

Eligibility Criteria

• Age: 45 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women between 45-85 years of age
• Clinical diagnosis of Parkinson disease
• Able to stand unsupported for 1 minute
• Able to walk 18 metres without aid
• Able to mount a stationary bike

You may not qualify if:

• History of dementia
• History of stroke
• Type 1 diabetes
• Autonomic neuropathy
• Currently involved in formal exercise training (\>3 day per week).

Sponsors & Collaborators

• University of Guelph: lead
• Parkinson Society Canada: collaborator
• YMCA: collaborator

Study Sites (1)

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Philip Millar, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The collection of study outcomes will be completed by individuals blinded to group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be randomized to 10 weeks of either high intensity interval training or continuous moderate intensity training. Training will be conducted in parallel.

Study Record Dates

• First Submitted: April 29, 2019
• First Posted: May 7, 2019
• Study Start: June 12, 2019
• Primary Completion: July 12, 2022
• Study Completion: July 12, 2022
• Last Updated: July 28, 2022

Record last verified: 2022-07

Locations

CA (1)