NCT03648749

Brief Summary

This study will evaluate the effectiveness of a speech-to-noise feedback procedure for the treatment of hypophonia in Parkinson's disease. The procedure includes a device that records the sound intensity level of the wearer's speech and compares it to the noise level around them. The device will provide the wearer with feedback if their speech becomes too quiet for them to be heard by their listener.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
25

participants targeted

Target at P25-P50 for not_applicable parkinson-disease

Timeline
Completed

Started Mar 2019

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 22, 2018

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 27, 2018

Completed
6 months until next milestone

Study Start

First participant enrolled

March 1, 2019

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2020

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2020

Completed
Last Updated

February 11, 2019

Status Verified

February 1, 2019

Enrollment Period

1.2 years

First QC Date

August 22, 2018

Last Update Submit

February 7, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Average speech-to-noise ratio

    Average speech-to-noise ratio value will be obtained over a two-hour interval.

    Single two-hour visit.

Secondary Outcomes (2)

  • Percent Speech Intelligibility Score (PSIS)

    Single two-hour visit.

  • Ratings of Experience with the Device

    Single two-hour visit.

Study Arms (1)

Speech-to-noise feedback

EXPERIMENTAL

A target speech-to-noise level is specified and feedback about achievement of the target level is provided

Behavioral: Speech-to-noise feedback

Interventions

A target speech-to-noise level is specified and feedback about achievement of the target level is provided.

Speech-to-noise feedback

Eligibility Criteria

Age45 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • diagnosed with idiopathic Parkinson's disease and hypophonia by a neurologist at least 6 months prior to participation.
  • stabilized on antiparkinsonian medication.
  • good general health.
  • pass a 40 decibel hearing screening.
  • proficient enough in English to participate in speech testing.

You may not qualify if:

  • history of stroke or an additional neurological or motor control disorder.
  • history of speech impairment that is unrelated to Parkinson's disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

LawsonHRI

London, Ontario, N6G 1H1, Canada

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Officials

  • Scott Adams, PhD

    Western University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Scott Adams, PhD

CONTACT

Mandar Jog, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: A single group will be studied during no intervention (no feedback about speech) and intervention (feedback about speech) phases.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 22, 2018

First Posted

August 27, 2018

Study Start

March 1, 2019

Primary Completion

April 30, 2020

Study Completion

December 31, 2020

Last Updated

February 11, 2019

Record last verified: 2019-02

Data Sharing

IPD Sharing
Will not share

Locations