Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

NCT03808363 | Completed

• 1 other identifier: 18-022-DITOR
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

Conditions

Metabolic Syndrome; Cardiovascular Diseases

Keywords

Metabolic Syndrome; Spinal Cord Injury; Cardiovascular Disease; High Intensity Interval Training

Outcome Measures

Primary Outcomes (12)

• Waist circumference (inches)

  Central adiposity will be measured by tape measure to monitor possible weight loss

  6 weeks

• Cholesterol

  Total and HDL cholesterol will be measured in serum

  6 weeks

• Triglycerides

  Triglycerides will be measured in serum

  6 weeks

• Glycated Hemoglobin (HbA1c)

  Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk

  6 weeks

• Tumor necrosis factor (TNF-a)

  TNF-a will be used as an inflammatory representative and will be measured in serum

  6 weeks

• Interleukin - 10 (IL-10)

  IL-10 will will be used as an anti-inflammatory representative and will be measured in serum

  6 weeks

• Pulse Wave Velocity

  Arterial stiffness, a common measure for cardiac risk will be measured

  6 weeks

• Blood pressure

  Measured through a digital cuff, the focus will be on both systolic and diastolic

  6 weeks

• Peak Oxygen Consumption (VO2 peak)

  VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness

  6 weeks

• C Reactive Protein (CRP)

  CRP will will be used as an inflammatory representative and will be measured in serum

  6 weeks

• Leptin

  Leptin will will be used as a body fat representative and will be measured in serum

  6 weeks

• Adiponectin

  Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum

  6 weeks

Secondary Outcomes (1)

• Physical Activity Enjoyment Scale (PACES)

  6 weeks

Study Arms (1)

High Intensity Interval Training Group

EXPERIMENTAL

Approximately eight individuals with spinal cord injuries will participate in high intensity interval training for 6 weeks

Other: High Intensity Interval Training

Interventions

High Intensity Interval Training OTHER

Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light - very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks.

Also known as: HIIT

High Intensity Interval Training Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury.
• Declared medically stable, and able to communicate clearly in English.

Sponsors & Collaborators

• Brock University: lead

Study Sites (1)

Brock University

Saint Catherines, Ontario, Canada

Location

MeSH Terms

Conditions

Metabolic Syndrome; Cardiovascular Diseases; Spinal Cord Injuries

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Mitchel Gibson, BKin

  Masters Student

  PRINCIPAL INVESTIGATOR

• Aaron Donst, BKin

  Masters Student

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: David Ditor, PhD - Professor, Kinesiology

Model Details: 6 week exercise intervention testing the efficacy of high intensity interval training as compared to current research supporting moderate intensity continuous exercise as a means to mitigate cardiometabolic decline following spinal cord injury

Study Record Dates

• First Submitted: October 22, 2018
• First Posted: January 17, 2019
• Study Start: February 1, 2019
• Primary Completion: May 30, 2019
• Study Completion: December 15, 2019
• Last Updated: January 18, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)