Effect of Nephrostomy on Relative Function of Obstructed Kidney

NCT03936673 | Completed

• 1 other identifier: 2014/349
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Urinary tract obstruction is a serious health problem due to kidney damage. Relative renal function has an important role in the treatment of obstructed kidneys. Nephrectomy can be recommended when the relative renal function is 10% or less in radionuclide examinations. Recently, however, nephron sparing approaches have come to the fore. This indicated the need to evaluate the possibility of recovering the function of the kidney before nephrectomy. The aim of this study is to compare relative functions of obstructed kidneys in technetium 99m dimercaptosuccinic acid scintigraphy (DMSA) before and 2 weeks after nephrostomy tube.

Conditions

Obstructive Uropathy

Keywords

obstructive uropathy; relative renal function; DMSA

Outcome Measures

Primary Outcomes (3)

• serum creatinine level 2 weeks after nephrostomy

  serum creatinine level 2 weeks after nephrostomy

  2 weeks after nephrostomy

• Serum BUN level 2 weeks after nephrostomy

  Serum BUN level 2 weeks after nephrostomy

  2 weeks after nephrostomy

• RRF in DMSA 2 weeks after nephrostomy

  RRF in DMSA 2 weeks after nephrostomy

  2 weeks after nephrostomy

Study Arms (1)

atrophic kidney

EXPERIMENTAL

Patients diagnosed with unilateral obstructed kidney with RRF 10% or less underwent application of percutaneous nephrostomy tube on affected side.

Procedure: Percutaneous nephrostomy

Interventions

Percutaneous nephrostomy PROCEDURE

atrophic kidney

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Unilateral obstructed kidney with RRF 10% or less
• Unilateral obstructed kidney with grade 2 or more hydroureteronephrosis
• Defined etiology for unilateral obstructed kidney
• estimated glomerular filtration rate (GFR) ≥ 30ml/min
• Approving the nephrostomy procedure

You may not qualify if:

• Unilateral obstructed kidney with RRF above 10%
• Estimated GFR \<30 ml/min
• diagnosis of bilateral obstructed kidneys
• not approving nephrostomy

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Department of Urology, Ercieys University, Faculty Of Medicine,

Kayseri, 38039, Turkey (Türkiye)

Location

Related Publications (8)

• Thorup J, Jokela R, Cortes D, Nielsen OH. The results of 15 years of consistent strategy in treating antenatally suspected pelvi-ureteric junction obstruction. BJU Int. 2003 Jun;91(9):850-2. doi: 10.1046/j.1464-410x.2003.04228.x.

  PMID: 12780846 BACKGROUND

• Gupta DK, Chandrasekharam VV, Srinivas M, Bajpai M. Percutaneous nephrostomy in children with ureteropelvic junction obstruction and poor renal function. Urology. 2001 Mar;57(3):547-50. doi: 10.1016/s0090-4295(00)01046-3.

  PMID: 11248637 BACKGROUND

• Ismail A, Elkholy A, Zaghmout O, Alkadhi A, Elnaggar O, Khairat A, Elhassanat H, Mosleh A, Hamad B, Elzomer J, Elkaabi A. Postnatal management of antenatally diagnosed ureteropelvic junction obstruction. J Pediatr Urol. 2006 Jun;2(3):163-8. doi: 10.1016/j.jpurol.2005.07.005. Epub 2005 Aug 26.

  PMID: 18947602 BACKGROUND

• Morduchowicz G, Winkler J, Zabludowski JR, Boner G. Effects of residual renal function in haemodialysis patients. Int Urol Nephrol. 1994;26(1):125-31. doi: 10.1007/BF02768252.

  PMID: 8026917 BACKGROUND

• Wang AY, Wang M, Woo J, Law MC, Chow KM, Li PK, Lui SF, Sanderson JE. A novel association between residual renal function and left ventricular hypertrophy in peritoneal dialysis patients. Kidney Int. 2002 Aug;62(2):639-47. doi: 10.1046/j.1523-1755.2002.00471.x.

  PMID: 12110029 BACKGROUND

• Bargman JM, Thorpe KE, Churchill DN. Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study. J Am Soc Nephrol. 2001 Oct;12(10):2158-2162. doi: 10.1681/ASN.V12102158.

  PMID: 11562415 BACKGROUND

• Zhang S, Zhang Q, Ji C, Zhao X, Liu G, Zhang S, Li X, Lian H, Zhang G, Guo H. Improved split renal function after percutaneous nephrostomy in young adults with severe hydronephrosis due to ureteropelvic junction obstruction. J Urol. 2015 Jan;193(1):191-5. doi: 10.1016/j.juro.2014.07.005. Epub 2014 Jul 9.

  PMID: 25014578 RESULT

• Aziz MA, Hossain AZ, Banu T, Karim MS, Islam N, Sultana H, Alam MI, Hanif A, Khan AR. In hydronephrosis less than 10 % kidney function is not an indication for nephrectomy in children. Eur J Pediatr Surg. 2002 Oct;12(5):304-7. doi: 10.1055/s-2002-35956.

  PMID: 12469255 RESULT

MeSH Terms

Interventions

Nephrostomy, Percutaneous

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Urological; Diagnostic Techniques and Procedures; Diagnosis; Ostomy; Surgical Procedures, Operative; Nephrotomy; Urologic Surgical Procedures; Urogenital Surgical Procedures; Urinary Diversion

Study Officials

• Abdullah T Demirtas, Assoc Prof

  Erciyes University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Md, Assoc Prof

Model Details: Patients diagnosed with unilateral obstructed kidney with RRF 10% or less underwent application of percutaneous nephrostomy tube on affected side.

Study Record Dates

• First Submitted: May 1, 2019
• First Posted: May 3, 2019
• Study Start: July 1, 2014
• Primary Completion: May 31, 2018
• Study Completion: January 1, 2019
• Last Updated: May 3, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)